The Effects Of Compound Xinluotai To Perimenopausal "Kindey Deficiency Phlegm And Blood Stasis Card" And The Alzheimer's On The Level Of Neuroendocrine

[Objective]Through the perimenopausal "kidney deficiency phlegm and blood stasis card" animal model of AD and in animal models of estrogen and monoamine neurotransmitters (dopamine,5-HT) A comparative study, observed in the two aspects of neuroendocrine And the relevance of traditional Chinese medicine compound Xinluotai its impact on Thailand for clinical from the perimenopausal for AD prevention and treatment provided on the basis of experimental and theoretical basis.[Approach]Female mice, the general level, 36, Bilateral ovarian surgery, after animals were randomly divided into two groups, as an ordinary diet group (12) and high-fat diet group (24); ordinary diet group To the general feeding, high-fat diet group were given high fat feeding, 10 days later, measured blood lipids, blood indexes to determine the success or failure of modeling. After the success of modeling, high-fat diet group were randomly divided into two groups, were perimenopausal "kidney deficiency phlegm and blood stasis card" model group (11) and perimenopausal "kidney deficiency phlegm and blood stasis card" treatment group (12). Ordinary diet group as a castration control group, named as Group A; perimenopausal "kidney deficiency phlegm and blood stasis card" model group named group B, perimenopausal "kidney deficiency phlegm and blood stasis card" treatment group named group C. Election SAM (P10) female mice as a model AD, the general level, 24, were randomly divided into two groups, AD is the model group (12) and the AD administration (12). AD model group named as Group D, AD administration group named group E. Below these two mice according to the dosage: C and E group to group, "Thai compound Xinluotai " strong decoction 22.5 ml / Kg, twice, gavage administration. Group A, B and D groups were given equal volume of saline, gavage administration. 8 weeks after delivery, using radioimmunoassay method for measuring serum estradiol levels by immunohistochemical determination of dopamine, 5 - serotonin content.[Results]1 Group B and Group D compare with the group A, the serum estradiol were significantly decreased, with a very significant difference (P<0.01); group C and group E compare with the model group serum estradiol levels increased significantly, A significant difference (P<0.05); However, Group B and Group D between estradiol levels, no significant difference (P>0.05).2 Group B and Group D compare with the group A, dopamine levels decreased significantly, with a very significant difference (P<0.01); D Group of dopamine in a further reduction in group B, compared with the two most significant difference (P<0.01); group C and group B increased levels of dopamine, a significant difference (P<0.05); group E and the group D, the dopamine levels increased significantly, with a very significant difference (P<0.01).3 Group B and Group D compare with the Group A , 5 - serotonin were significantly reduced, compared with the two most significant difference (P<0.01); D Group 5 - serotonin in a further reduction in group B, two Compared with a very significant difference (P<0.01); group C and group E compare with the model group 5 - serotonin were significantly higher, with significant differences (P<0.05).[Conclusion]Through experiments show that perimenopausal "kidney deficiency phlegm and blood stasis card" animal model of AD and in animal models with neuroendocrine normal perimenopausal compared with the same animal model of performance for the neurotransmitter content and a lower level of estradiol , But to different degrees. And traditional Chinese medicine "compound Xinluotai " strong decoction with marked improvement in their role, so as to clinical from perimenopausal women began to control Alzheimer's study to provide experimental basis.