A Systematic Review Of Chronic Hepatitis B

Objectives: Carry on qualitative and the quantitative analysis on randomized controlled trials (RCT) of clearing away heat and expelling dampness to therapies for chronic hepatitis B since 1994 to 2008 with Evidence-based medicine method,providing the best proof for the clinical reatment,and lay foundation for carrying on further study.Method:(1) With the searching terms,pick out the titlerecords of Traditional Chinese Medical (TCM) therapyies for chronichepatitis B which including the words "random".(2) Randomised or quasi randomised clinical trials of TCM therapies for chronic hepatitis B were selected for this study. (3) The evidence-based medicine's method will be abided by for the study. The evaluation of methodological quality of clinical trials will be carried on according to the request of Cochrane manual , including allotment method of randomization,concealment of allocation sequence,blind method,withdraw or lose to visit case number and reason,intention-to-treatanalysis and so on.Main results: 501 articles were found from881pieces of title recordsconcerning this kind of literature,40.1% of which took the design of randomized trial control,and last got 236 full texts. randomized clinical trials (RCTs) and pseudo-randomized clinical trials involving 1616 chronic hepatitis B patients were identified that tested.Traditional Chinese medical therapeutic effect. The appraisal content mainly includes carrying on the circumstan-ces and the qualitative analysis on selected ordinary clinicaltrials. Carry on Meta analysis on selected randomized controlled trials(RCT) about the treatment of CHB with matrine,oxymatrine, and other Chinese herbs.Conclusion:At present,the quantity of RCT on Traditional Chinese Medicine(TCM) therapies for chronic hepatitis B has raised sharply year by year,and the quality of the studies has enhanced increasingly,however its methodological quality was poor in total. The overall trial design level of clinical studies in this aspect need enhance urgently due to the demands of clinical practice. Both the total efficient rate and theanti-virus effect of the matrine are better than the contrast obviously.Oxymatrine are effective drug for CHB.The other Chinese medicine need be ananlyized again after getting large numner of articals.