Study On The Phlegm-damp Syndrome Of Cases With Impaired Glucose Regulation

Objective:To explore the characteristics of glucose and lipid metabolism in Phlegm-damp Syndrome of cases with impaired glucose regulation(IGR).Materials and methods:According to diagnostic criteria of IGR published by WHO in 1999 and differentiation standard of Phlegm-damp Syndrome made by the Consumptive Thirst Committee of China TCM Society in 1992,We selected 60 cases of IGR patients,30 cases of phlegm-damp-positive and 30cases of negative types,27 males and 33 females,age from31～70 years old.The average age was 49.68±8.67 years old.The average body mass index(BMI) was 25.70±3.05kg/m~2.Another 20 examples was selected as normal group in addition,including 8 males and 12 females,age 28～73 years old.And the average age was 47.90±11.53 years old.All of them should tell their clinical symptoms by themselves first,and then be inquired by doctors.At the same time,they were examined the targets as below:the blood glucose measurement used glucose oxidase method;the serum lipid determination used enzymatic method;the determination of plasma insulin used highly sensitive Radioimmunoassay(RIA);the determination of free fatty acids(FFAs) used immunity transmission turbidity.The BMI was calculated used the ratio between weight and square of the height.Insulin resistance was calculated using the homeostasis assessment(HOMA)(HOMA-IR=FPG×FINS/22.5).Results:1.Compared with the health control cases,the FFAs,BMI,FPG,OGTT2hPG,FINS and HOMA-IR of patients with IGR were significantly higher(P＜0.01).2.Compared with the non-phlegm-damp cases with IGR,the FFAs,BMI,FINS and HOMA-IR of phlegm-damp subjects with IGR were significantly higher(P＜0.01),and the level of TG was higher also(P＜0.05).3.The HOMA-IR was positively correlated to BMI,FFAs and TG(P＜0.01 or P＜0.05). And there was an intimate relationship between FFAs and HOMA-IR(The interrelated coefficient was more than 0.5.).Conclusion:1.Compared with the non-phlegm-damp cases with IGR,the HOMA-IR of phlegm-damp subjects with IGR is higher.It implies that Phlegm-damp Syndrome with IGR is closely related to insulin resistance. 2.Compared with the non-phlegm-damp cases with IGR,the BMI,TG and FFAs of phlegm-damp subjects with IGR is higher.It implies that the high level of BMI,TG and FFAs can be used as reference index for Phlegm-damp Syndrome with IGR.3.The HOMA-IR is positively correlated to FFAs and TG.It implies that the disorder of lipids metabolism plays an important role in the pathogenesis of insulin resistance in Phlegm-damp Syndrome with IGR.