Clinical Effect And Influence Of Serum Vascular Endothelial Growth Factor On Ginsenoside Rg3 Plus Chemotherapy In Non-Small Cell Lung Cancer Patients

Lung carcinoma is one of the most familiar malignant tumours of international community currently.It has already become the main cause of death of malignant tumors,and the mortality will raise gradually.The growth of tumors is vessel-dependent.Therefore,anti-angiogenetic therapy has become one of the heat points in cancer research fled.Ginsenoside Rg3 is a kind of effective chemical component extracted tracely from the Red Ginseng,which can directly inhibit tumor angiogenesis and induce tumor.It was said that chemotherapy combined with Ginsenoside Rg3 was a logical potentially powerful treatment.Objectives:1.To evaluate the influence of serum vascular endothelial growth factor on Ginsenoside Rg3 combined with chemotherapy in patients with non-small cell lung cancer,and approach the mechanisms on neovascularization.2.To obvserve the clinical anticancer of Ginsenoside Rg3 plus chemotherapy in non-small cell lung cancer patients;.Methods:Forty-one patients with non-small lung cancer were selected in Fuzhou general hospital.The patients were randomized into two groups:Group A were treated with systemic chemotherapy,Group B with Ginsenoside Rg3 plus systemic chemotherapy.The gross tumor volume and the score of quality of life was evaluated,and the level of serous vascular endothelial growth factor was detected by using of enzyme linked immunosorbent assay.Results:1.Curative Effect:The recent response rate was 33.3%(7/21)in group B,and 20% (4/20) in group A(P＞0.1).The disease control rate was 76.2%(16/21)in group B,and 45% (9/20) in group A(P＜0.05).2.Quality of Life:The rate of Quality of Life improvement was66.7%in group B,and 35%(7/20) in group A(P＜0.05).3.sVEGF level:①Before treatment:The level of sVEGF was 324.04±71.61 pg/ml in stageⅣpatients,195.33±48.96 pg/ml in stageⅢ,55.20±9.47 pg/ml in healthy population(P＜0.05).The level of sVEGF was 277.15±97.69 pg/ml in group A,and 276.76±83.07 pg/ml in group B(P＞0.1).②After treatment:The level of sVEGF was 243.65±65.64 pg/ml in group A,and 216.33±56.30 pg/ml in group B,with significant difference(P＜0.05).Conclusion:1.Ginsenosides Rg3 combined with chemotherapy could morely descended the level of sVEGF,which was the way to strengthen the effect of neovascularization.2. Preliminary results show improvements in response rate and quality of life in Ginsenosides Rg3 combined with chemotherapy.It is worthy to confirm the results in further clinical trials.