Expressions Of CD24 In Breast Invasive Ductal Carcinoma

Objective: To evaluate the expressions of CD24 in fibroadenoma and invasive breast carcinoma(IDCa) in different patterns ( including membranous and cytoplasmic staining ) , and to investigate the relationship between clinicopathological significances and Ki67.To study the expression changes of CD24 in IDCa after neoadjuvant chemotherapy.Methods: The expression of CD24 in 13 cases of fibroadenoma and the expressions of CD24 and the expression of Ki67 in 69 cases of IDCa were respectively studied by immunohistochemistry SP.Result: Positive rate of CD24 in IDCa was 80.43%;positive rate of fibroadenoma was 53.85%.The expression intensities of CD24 in IDCa was significantly higher than those in fibroadenoma ,and the differences between groups are of statistical significance(P<0.05). The expressions of CD24 were positively correlated with lymph node metastasis(P<0.05), but not with tumor size, pathologic grade, estrogen receptor(ER), progesterone receptor(PR), c-erbB-2, P53 and Ki67(P>0.05). The membranous of CD24 was positively correlated with ER,PR(P < 0.001).The CD24 expressions in IDCa have no significant changes after neoadjuvant chemotherapy(P> 0.05).Conclusion: The CD24 cytoplasma dyes only expresses in the mammary gland malignant tumor. Neoadjuvant chemotherapy has no influence on the CD24 expressions. High expression of CD24 may be related with invasion and metastasis of breast carcinoma and membranous expressions of CD24 are correlated with tamoxifen-resistant of breast cancer cases. It can be a marker of prognostic determination of breast carcinoma.