Discussion Of Dsg3 As A Prognostic Factor In Lung Cancer

Objective1.To investigate the expression of dsg3 in non-small cell lung cancer and carcinoid,and to discuss the reference of dsg3 with the size,staging,differentiation of the tumor tissue and gender,age of the patient. 2.To investigate the relationship of dsg3 and the 3-year, 5-year survival rate of lung cancer, the survival time after surgery of SCC,AD carcinoid and the expression of dsg3.Methods1. To follow up the surgery patients of tianjin chest hospital between Jan,2002 and Aug,2004 by telephone.58 non-small cell lung cancer patients and 12 caricinoid patients were obtained as an outcome,and 3-year survival, 5-year survival was also obtained according Keplan-Meier. The cilinical and pathological datas were also given. 2. The expression condition of dsg3 was detected in the 58 NSCLC tissues and 12 carcinoid tissues by immunohistochemical method. 3. Analyze the expression difference of dsg3 in each kind of NSCLC,discussion the relationship of the cilinical characteristic (gender,age) of the patients and size, staging,differentiation of the tumors. 4.Analyze the reference of dsg3 and 3-year survival, 5-year survival of the patients .Analyze the survival time after surgery of SCC,AD carcinoid and the expression of dsg3.Results1.The average St was obtained as 37.24±18.46 months,and the 3-year survival ,5-year survival was 60.34% and 43.75% by Kaplan-Meier. 2. The negative or masculine of dsg3 is closely associated with the survival of the patients ,the negative ones have a short survival (P<0.01) .We drawed survival curve of the 58 NSCLC patients,and the survival refered much with the expression of dsg3 .The St of the carcinoid, SCC, AD,patients is considered to be difference by t test (P<0.01) . 3. The expression of dsg3 is not associated with the cilinical factorssuch as age,gender. 4. The experession of dsg3 has a close relationship with the differentiation of the tumors. The low degreedifferentiation ones are negative compared to the high degree ones.Conclusions:1. The negative or masculine expression of dsg3 is asociated with the prognosis of lung cancer, and negative expression mostly cue a poor pronosis. 2.The expression of dsg3 is refered to the differentiation of the tumors,this study disclose that the high degree differentiation ones have a better masculine expression.