Clinical Analysis Of Infection In Patients With Malignant Tumors

Objective:To investigate the characters of infection in patients with malignant tumors,especially in correlated factors of infection, distribution and yearly changes of the pathogens,pathogens' resistance to common antibacterial agents,and provide information for clinical anti-infection therapy.Methods:Retrospective analysis was used to study the characters of infection in 3206 patients with malignant tumors in department of oncology in the Third Xiangya Hospital from Jan.2003 to Dec.2007. The data was processed by the software SPSS13.0,and X~2-test was used to analyse the correlated factors of infection in patients with malignant tumors.Results:1)The infection in patients with malignant tumors was associated with age of patient,time in hospital,type and clinical stage of tumors, basic diseases,radiotherapy,chemotherapy,invasive operations, myelosuppression,the use of hormones and broad-spectrum antibiotics.But surgery treatment was not correlated with infection.2)The respiratory tract was the most frequent infection site(61.1%). The infection was mainly caused by opportunistic pathogens.46.3%of the pathogens were the Gram-negative bacteria which mainly consist of Pseudomonas aeruginosa,Escherichia coli,Acinetobacter baumannii. 29.9%of the pathogens were Gram-positive bacteria which mainly consist of Staphylococcus aureus and Staphylococcus epidermidis,and the rest 23.8%of the infection was caused by different kinds of fungi which mainly consist of Candida albicans.3)The ratio of the Gram-negative bacteria's resistance to such antibiotics as penicillins,cephalosporins(except ceftazidime), sulfanilamides,tetracyclines and quinolones was higher.The ratio of the Gram-positive bacteria's resistance to such antibiotics as penicillins, macrolides and quinolones was higher.And the ratio of the fungi's resistance to such antibacterial agents as fluconazol and itraconazole was higher.4)The infection caused by fungi increased obviously in the past five years.Conclusions:1)The infection in patients with malignant tumors was mainly caused by the opportunistic pathogens,and the pathogens' resistance to antibacterial agents was serious.2)The infection caused by fungi had an increase trend.We should pay attention to this phenomenon.3)Dynamic observation of the changes in infection and drug resistance can provide information for clinical anti-infection therapy.