The Study Of Association Between SNP 1425G/A In PRKCH And Genetic Susceptibility Of Cerebral Infarction

Objective:To explore the association between 1425G/A single nucleotide polymorphism(SNP)of Protein kinase C_ηgene(PRKCH)and cerebral infarction in Jiangsu Han population.Methods:255 patients with cerebral infarction and 225 controls were recruited in our case-control study.The 1425G/A in PRKCH gene was detected by direct sequencing of PCR products.Data were coded and entered in SPSS Windows(version 13.0).Results:The frequencies of the GA+AA genotypes(56.86%)and A allele(36.27%)in CI group were significantly higher than those in control group(44.44%and 24.67%;x~2=7.377,p=0.007 and x~2=15.104, p＜0.001).Further analysis indicated that the genotypes(63.09%)and alleles(40.27%)frequencies were statistically different between lacunar infarction subtype and controls(44.44%and 24.67%;x~2=11.744,p= 0.001 and x~2=20.445,p＜0.001).Logistic regression analysis revealed that hypertension,diabetes mellitus,hyperlipidemia and the A allele of 1425G/A polymorphism were independent risk factors for lacunar infarction.Conclusions:The SNP 1425G/A in PRKCH was significantly associated with cerebral infarction,particularly with lacunar infarction.