Observation Of Neuromuscular Blockade Effects Of Cisatracurium On Rapid Endotracheal Intubation

Objective To observe the neuromuscular blockade effects and side effects of cisatracurium on rapid endotracheal intubation.Methods Sixty patients were randomized to three groups(n=20):A group(cisatracurium, 2min),B group(cisatracurium,3min),C group(cisatracurium,4min).All patients were anesthetized with intravenously injection of midazolam(0.05mg·kg^-1),fentanyl(2μg·kg^-1),etomidate(0.3mg·kg^-1) and cisatracurium(0.15mg·kg^-1).Then the haemodynamical changes before and 1～15min after administration of the relaxant were recorded,the neuromuscular blockade and side effects of groups were also observed.Results The intubation situationof B,C groups was better than A group.The B,C groups had no significant differences(P＞0.05).The haemodynamical changes had no significant differences(P＞0.05).But the Bp and HR after lmin of intubation were higher than ante-intubation within group.The side effects had no significant differences in 3 groups (P＞0.05).Conclusion The intubation situation can achieve best at 3min after administration of the cisatracurium(0.15mg·kg^-1).Cisatracurium does not affect plasma histamine concentration and haemodynamics.It can be safely used in the rapid endotracheal intubation of general anesthesia with satisfactory neuromuscular blocking effects.