Human Papillomavirus Genotype Distribution In Invasive Squamous Cell Carcinoma Of The Uterine Cervix In Inner Mongolia Autonomy Region

Objective Retrospective investigate the prevalence of human papillomavirus(HPV) and genotype distribution in invasive squamous cell carcinoma of the uterine cervix in inner Mongolia autonomy region,to provide reference for cervical cancer prevention in inner Mongolia. Methods 63 paraffin - embeded samples of cervical cancer were collected in inner Mongolia hospital in the years 1996 to 2006,which all are squamous cell carcinoma of the uterine cervix.A sandwich technique of paraffin section was used to avoid cross contamination between different specimens.INNO - LIPA genotyping technique was used to detect HPV genotypes,the overall positive rate of HPV and the positive rates of different HPV genotypes.All data were analyzed by statistics methods with SPSS13.0 software.Throughout the paper,Chi-square for cross - table was used for all numeration data and P＜0.05 was considered statistically significant.Results The prevalence rate of HPV is 93.7%; The positive rate of different HPV genotypes is HPV16(69.8%),HPV18(4.8%),HPV31 (4.8%),HPV39(4.8%),HPV52(3.2%),HPV45(1.6%),HPV51(1.6%),HPV54(1. 6%),HPV58(1.6%).The positive rates of HPV in different clinical staging and pathological grading are not significantly different.(P＞0.05),prevalence of HPV16 has no significant difference in different in different ages(P＞0.05).HPV16(69.8%),HPV18(4. 8%),HPV31(4.8%),HPV39(4.8%)and HPV52(3.2%)are the 5 dominant HPV genotypes of all cases.There is only single type - HPV infection no multiple type- HPV infection in all specimens.Conclusions HPV infection is closely related to invasive squamous cell carcinoma of the uterine cervix of Mongolia women.HPV16 is the most important genotype in invasive squamous cell carcinoma of the uterine cervix of Mongolian woman,which followed by HPV18,31,39.HPV infection dose not affect the progress nor differentiation of invasive squamous cell carcinoma of the uterine cervix of Mongolian woman.