Effects Of Learning On The Ability Of Memory And The Expression Of BDNF And Aβ In The Brain Of D-galactose-induced Dementia Mice

As the improvement of living standards and medical advances in technology, the people's life-span is prolonging. The percentage of aged in total population is growing, so how to handling the health of aged is becoming a problem to take attention. The preservation and therapy of senile dementia is one of the focuses in the medicine fields in the future. At present there's no effective method to cure dementia, although some drug treatment effects, but a long course of treatment and the high cost made the family and society with a heavy financial burden.Actually AD is due to the accumulation of long-term negative factors and the pathogenetic process is long. Often there are serious brain damage and dysfunction when it happens. It's blindness that drug is given aimed at pathogenesis before preventive intervention, and people accept it difficultly. Epidemiological studies show that the incidence of dementia in a higher level of education are low, which suggests that their learning activities for the prevention or delay the occurrence of dementia could play a positive role, but the learning activities to prevent or delay dementia in the mechanism also lack of in-depth study. In this study, the model mouse of AD was adopted by intraperitoneal injection of D-galactose, and we use eight-arm actinomorphic maze to train the mice for a long time and detect the aging mice's ability of learning by training with jumping platform to test whether the training elevate the ability of finishing other tasks. Immunohistochemical methods used to observe the expression levels on the Aβ1-40/42 and BDNF in brain after learning and training.Results:1. The learning and training with the maze elevate the learning and memory ability by jumping platform.2. The expression of Aβand CA1 in hippocampal was significantly higher level after the mice were injected D-galactose, but learning and training can reduce Aβexpression levels in BLA. Compared to normal mice, the learning and training impacted the aging mice was more obvious.3. The BDNF expression of BLA and VMH was in the lower level after the mice were injected D-galactose. Learning and training can significantly improved the D-galactose-induced aging mice's expression level of BDNF in CA1 and BLA.These results suggested that learning and training not only can improve the mice's capability of learning and remember different tasks to some degree but also can enhance the expression of BDNF in some brain areas and reduce the deposition level of the Aβ. The course of learning and training could modulate the expression of Aβand BDNF and signal transduction process may be one of the important mechanisms in delaying and preventing aging.