Study And Expression Of Serum Soluble Intercellular Adhesion Molecule-1 In Obeses Women With Polycystic Ovarian Syndrome

OBJECTIVE: To investigate plasma soluble intercellular adhesion molecule-1 (sICAM-1) concentration in obese women with polycystic ovary syndrome (PCOS), and the association between obese women with polycystic ovary syndrome and cardiovascular disease, as well as their clinic significance.METHODS: From June 2005 to July 2007, in out-patient clinic department of gynecology of the first affiliated hospital of Guangxi Medical University, selected randomly 54 women with polycystic ovary syndrome for experimental group, 61 women whose menstruation was normal and without Polycystic ovary syndrome for control group. According to BMI≥24kg/m² or WHR≥0.8, all the subjects were divided into obese group and non-obese group. There were no significant deviation in age, weight and height between experimental and control group (P>0.05). All subjects were collected venous blood in early morning without eating from 3^rd to 5^th in menstrual period (amenorrhea no limit), meanwhile were measured all subjects' height(m), weight(kg), waist circumference(cm), hip circumference (cm) and sex hormone level, then calculated body mass index(BMI) and waist-to-hip ratio(WHR). Otherwise according to BMI≥24kg/m² or WHR≥0.8, all the subjects were divided into obese subgroup and non-obese subgroup respectively, measured the level of sICAM-1 in serum with Enzyme Linked Immunosorbent Assay(ELISA). Then compared the variability between experimental and control group, and did the multiple linear regression analysis between sICAM-1 and clinic indexes above.RESULT: 1.Serum sICAM-1 level was dependent with BMI and WHR respectively(P<0.05); serum sICAM-1 level in obese group was higher than non-obese group(P<0.05); 2.serum sICAM-1 level in PCOS group was higher than the control group(P<0.05); serum sICAM-1 level in PCOS obese subgroup was higher than the PCOS non-obese subgroup(P<0.05); serum sICAM-1 level in control obese subgroup was higher than the control non-obese subgroup(P<0.05); serum sICAM-1 level in PCOS non-obese subgroup was higher than the control non-obese subgroup(P<0.05); serum sICAM-1 level in PCOS non-obese subgroup was lower than the control obese subgroup(P<0.05); there was no significant deviation in serum sICAM-1 level between PCOS obese subgroup and control obese subgroup(P>0.05); there was no significant deviation in serum sICAM-1 level between the patients with WHR≥0.8 and BMI≥24kg/m² and the patients with WHR≥0.8 and BMI<24kg/m²(P>0.05); 3. Displayed by multiplicity, serum sICAM-1 level had positive correlation with group, age, BMI, WHR, and testosterone.CONCLUSION: Our study showed that there is close correlation between sICAM-1 and PCOS, the women with PCOS have risk of cardiovascular diseases. And the age is older, BMI is bigger, the WHR is bigger, the serum testosterone lever is higher, the serum sICAM-1 level of PCOS patients is much higher. So we must monitor PCOS patients closely, especial PCOS central obese patients, in order to prevent cardiovascular diseases.