Expression Of E-cadherin And MMP-9 And Analysis Of Multiple Prognostic Factors In Gastrointestinal Stromal Tumor

Objective:To investigate the relationship between the expression of E-cadherin,matrix metalloproteinases 9,and the prognosis of gastrointestinal stromal tumor(GIST).Methods:The clinical and pathological data of 78 patients with GISTs admitted between April 2002 and June 2006 in Xiangya Hospital were analyzed.To refer to Flecher's classification in GISTs, immunohistochemical technique was used to investigate the expression of E-cadherin and MMP-9.To investigate the impacts of clinical feature,pathologic classification,expression of E-cadherin and MMP-9 on the 2-year recurrence and metastasis rate and 5-year survival rate in patients with GISTs.Results:The positive rate of E-cadherin were 65.4%(51/78)and the positive rate of MMP-9 were 55.1%(43/78)The expression of E-cadherin and MMP-9 had no significant difference in gender,age (P＞0.05),but had significant difference in localization of tumor and the histological grade(P＜0.05).There was negative correlation between the expression of E-cadherin and MMP-9(C=0.908).The 2-year recurrence and metastasis rate and 5-year survival rate were 31.8%,72.3% respectively.No significiant differences in gender and age were existed. Primary organ,Tumor size,mitotic rate and expression of E-cadherin, MMP-9 were analysized respectively.The differences were significiant (P＜0.05).There were significiant differences in expression of E-cad in multiple factors analysis.Conclusion:The expression of E-cadherin and MMP-9 are closely related to the biological behavior of GIST,which may be used as an objective parameter for distinguishing malignant from benign GIST. Primary organ,tumor size,mitotic rate and expression of E-cadherin,MMP-9 are important prognostic factors in GIST,and the expression of E-eadherin is independent prognostic factor.E-cadherin may be an indicator to forecast the recurrence and metastasis rate of GIST. To combine Fleeher's classification and the expression of E-cadherin, MMP-9 may be a more ratinal,scientific method in GIST's prognostic analysis.