Pharmacokinetics Parameter Of Nickel And Effects Of Cadmium On Residual Medicine Of Nickel In Rats

The absorption distribution and excretion of ⁶³Ni-NiCl₂ in Rat were studied by using Liquid scintillation counting method,It was observed that the concentration-time curves in blood fitted the two dicompart-ment model of pharmacokinetics,Ka=6.18h,T_1/2(α)=0.79h,T_1/2(β)=40.68h,CL=0.42mL/(kg·h), T(peak)=0.53h,C(max)=14.99MBq/L,V(d)=0.016L/Kg.⁶³Ni-NiCl₂ was existed in all 12 tissues tested;at 0.25h,radioactivity in intestine were the highest,and that in stomach and fattiness were higher;at 3h,liver,stomach and intestine were higher; the germen was the least;The liver and lung was the higher at 24h.In 24h 83.26%of radioactivity of oral administration was eliminated by urine and feces,54.86%by urine,28.41%by feces.After rats were treated by ⁶³Ni-NiCl₂ for 15days,in 22 tissues tested,the hair,hypothalamus,hypothesis,pancreas,small and large intestines were higher,and the residual medicine of ⁶³Ni-NiCl₂ wasn't discovered in liver,kidney and heart.Effects of CdCl₂ on tissue residual medicine of ⁶³Ni-NiCl₂ in Rats has been studied by isotope tracer,the experiment showed that ⁶³Ni-NiCl₂ has been found in 19 tissues tested in whole 22 tissues after infusing in stomach for 8d and lacking of food and water for 72h with 0mg/kg·bwCdCl₂+8.76MBq/kg·bw⁶³Ni-NiCl₂;After the same method with 0.5mg/kg·bwCdCl₂+8.76MBq/kg·bw⁶³Ni-NiCl₂,the result showed that the 7 tissues of all 21 tissues had some counts.After the above method with 1mg/kg·bwCdCl₂+8.76MBq/kg·bw⁶³Ni-NiCl₂,the result showed that only 2 tissues had counts,others weren't found.And after infusing in stomach for 8d and lacking of food and water for 72h with 10mg/kg·bwCdCl₂+8.76MBq/kg·bw⁶³Ni-NiCl₂,the count has been tested in 7 tissues,bone,eyeball,hair and so on.after infusing in stomach with 10mg/kg·bwCdCl₂+8.76MBq/kg·bw⁶³Ni-NiCl₂,11 tissues tested had counts.