Study On The Solubilization Of Liposoluble Constituent And In Vitro Release Mode Of Target Ingredient In Compound Danshen Sustained-Release Tablet

Objective: To increase the solubility of borneol and tanshinone in compound danshen sustained-release tablet , to prepare the borneol inclusion compound and the tanshinone dry emulsions,and to investigate in Vitro release mode of borneol, tanshinoneâ…¡A two species target ingredient in compound danshen sustained-release tablet. Methods:â‘ The borneol compound were prepared after optimizing the incluse technology by the L₉(3⁴) orthogonal design test, using the yield of inclusion compound and inclusion rate of berneol as the evaluation index. The borneol dissolubility are compared with its compound.â‘¡The tanshinone dry emulsions were prepared after optimizing the support agent of dry emulsions by the U₇(7³) uniform design test, using the appearance quality , redissolving effect and solubility as the evaluation index. The tanshinone dissolubility are compared with its dry emulsions.â‘¢The compound danshen sustained-release tablet are prepared by borneol compound, tanshinone dry emulsions and other materials. After the release rate test, the release mode of liposolubility target ingredient were analyzed, the release mode of water-solubility target ingredient salvianolic acid B and panaxsaponin Rg1 also were analyzed. Result:â‘ The prepared borneol inclusion compound following the optimized incluse technology is well , the inclusion rate of berneol is 94.13% and the yield of inclusion compound is 97.79%. The solubility of borneol was raised 28.34%, The total dissolve percentage of borneol from inclusion compound is persistenced in 100 min test in vitro, which of the crude borneol has reached to its peak in 50 min.â‘¡The prepared dry emulsion following the optimized support agent is well in quality results. After the tanshinone were prepared the dry emulsion, the solubility of tanshinone was raised 53 times. The total dissolve percentage of tanshinone from dry emulsion is 74.16% in 120 min test in vitro, while hardly does the crude drug perform any dissolution.â‘¢It was fitted that the release results of compound danshen sustained-release tablet with 1h to 10 h in water test, the best-fit model of borneol, tanshinoneâ…¡A and panaxsaponin Rg1 are first level model, the best-fit model of salvianolic acid B is Higuchi model. The Ritger-Pappas model results of four species target ingredient indicate that drugs release are non-fick diffusion.Conclusion:The liposoluble constituent were been to process by solubilizing, the solubility of borneol and tanshinone were remarkably increased. The release results of four species target have up to release requirements and to come true the equilibrate release of multi-target ingredient.