Expression Of KGF And E-cadherin In Pancreatic Adenocarcinoma And Their Clinic Significance

Objectives To study the expression of KGF and E-cadherin in pancreatic adenocarcinoma and their clinical significance.Methods The expression of KGF and E-cadherin in 45 specimens of paraffin-embeded pancreatic adenocarcinoma and 22 normal pancreas around tumors was detected by using immunohistochemistry staining(SP) and compared with clinicopathological data.Results (1) The positive rate of KGF expression in pancreatic adenocarcinoma was77. 8 % (35/ 45), and that in normal pancreatic tissue was 9.09%(2/22). There was statistical difference between them(P<0.01). (2) The positive rate of E-cadherin expression in pancreatic adenocarcinoma and in normal pancreatic tissue was 35.6%(16/45),95.5%(21/22),respectively. There was statistical difference between them(P<0.01). (3) There was no significant difference among the expression of KGF in different sex,ages,tumor location,tumor diameter of the cancer and the metastasis of lymph nodes, however there was a relationship with the differentiation of carcinoma and the clinical stages. (4) There was also no significant difference among the expression of E-cadherin in different sex,ages,tumor location and tumor diameter,however there was a relationship with the differentiation of carcinoma , the metastasis of lymph nodes and the clinical stages. (5) The expression between KGF and E-cadherin had a significantly negative relation in pancreatic adenocarcinoma (χ2=8.730, P<0.01). Relevance of them was measured by Pearson in numerical, C =0.445.Conclusions (1) KGF was highly expressed in pancreatic cancer and the expression of KGF was associated with the differentiation of carcinoma and the clinical stages, the expression of KGF was increased with the degradeing differentiated degree and the heightening the clinical stages,which indicated that it might be a useful tumor marker to assess the tumor's malignant behavior.(2) The expression level of E-cadherin in pancreatic carcinoma was signifcantly decreased compared with that in nearby tumor free tissues, and it was significantly correlated with the pathological grading, lymph node metastasis and the clinical stage, which indicated that E-cadherin was correlated with the tumor metastasis, proliferation, cancer progression and tumor cell adhesion of pancreatic carcinoma and it might be a useful tumor marker of pancreatic carcinoma.(3) The level of KGF and E-cadherin may be a sensitive predictor of proliferation ,differentiation , invasion and metastasis of pancreatic adenocarcinoma.