A 1:2 Matched Case-Control Study On Risk Factors Of Primary Hepatic Carcinoma

Objective: Through the investigation and the statistical analysis of Dalian Primary Hepatic Carcinoma patients to explore the related risk factors that affect the occurrence of Primary Hepatic Carcinoma, provide reference for the prevention of Primary Hepatic Carcinoma.Methods: A 1:2 matched case-control study was carried out in Dalian including 110 cases and 220 controls in synthesize hospital of Dalian from March, 2007 to March, 2008. The cases were patients of Primary Hepatic Carcinoma who were made a definite diagnosis and new hospitalization, and lived in Dalian city for 10 years and above. According to the principle of 1:2 matched case-control study, the control were non- tumor and no disease of digestive in the same period in the same hospital. The match conditions are same gender, younger or older 3 years old, and live in the city of Dalian for 10 years and above. The main contents of questionnaire included that general state of health, occupation, inhabited environment, life behavior, the history of disease, the family history of cancer, eating habit, and psychological factor et.al. Data were input to the computer by the software of EXCEL 2003 analyzed with Chi-square test, Nonparametric test and the conditional Logistic regression by the software of SPSS 13.0 and SAS 8.2.Results:1.There ware no statistics difference between the two group in the aspect that educational level, family income and living expenses, occupation and so on, but there ware difference in the facet that touching poisonous or noxious substance (χ~2=6.42, P=0.01). 2.Through reviewing the inhabited environment, we found that there were statistics difference between the two group in the aspect of weather the pollution factory exist near the inhabited address, weather decorating the house during the near ten years. 3. Through investigating the behavior, we found that there were statistics difference between the two groups in the aspect of smoking, drinking, exercising, staying up late or all night (OR=1.76,95%CI=1.02~ 3.01;OR=1.98,95%CI=1.14~3.46;OR=2.32,95%CI=4.12~3.77), and there were no statistics difference in the aspect of passive smoking, drinking tee. 4. There were statistics difference between the two groups in the aspect of the history of diabetes (χ~2=20.53, P=0.00), and the family history of cancer (χ~2=24.66,P=0.00). 5. In the dietary factor, eating frying food, seashell or garlic were relative with Primary Hepatic Carcinoma. 6. Through investigating the social psychic factor, we found that there were statistics difference between the two group in the aspect of experiencing the negative events, feeling pressure frequently, having the experience of pressure during a long time. According the multiple conditional logistic regression, there were close relationship between Primary Hepatic Carcinoma and the factors include that touching poisonous or noxious substance, stay up late or all night frequently, the history of diabetes, the family history of cancer, feeling pressure frequently, having the experience of pressure during a long time, eating garlic,seashell or frying food. Except eating garlic is the protective factor, the others were the risk factors of Primary Hepatic Carcinoma.Conclusion: There were close relationship between Primary Hepatic Carcinoma and the factors include that touching poisonous or noxious substance, stay up late or all night frequently, the history of diabetes, the family history of cancer, feeling pressure frequently, having the experience of pressure during a long time, eating garlic,seashell or frying food. Except eating garlic is the protective factor, the others were the risk factors of Primary Hepatic Carcinoma.