The Correlative Study Of Different Classification Of Liver Cirrhosis With Helicobacter Pylori Infection And Serum Ammonia Concentration

ObjectiveTo investigate the changes of Serum Ammonia Concentration in patients with Liver Cirrhosis after infecting Helicobacter Pylori (Hp) and to analysis the relationship between the different classification of Liver Cirrhosis with Helicobacter Pylori Infection and Serum Ammonia Concentration by the method of survey.MethodUsing the method of clinical epidemiologic study , and designing questionnaires included general informationLiver Cirrhosis etiology,TCM four consultation Hp infection,serum ammonia concentration,liver function renal function,coagulation etc. Traditional Chinese Medical syndromes of Liver Cirrhosis were divided into six different classifications: stagnation of liver-qi,superabundance of dampness,internal accumulation of damp-heat,asthenia of liver and kidney yin,asthenia of spleen and kidney yang and blood stasis. The questionnaires were filled out by the specialists, and traditional Chinese medical syndromes were approved by two experts according to the differentiation standards finally. The clinical observation was Implementated after training the study staff and amending the survey questionnaires. Statistical methods was analysed by SPSS13.0 statistics package. The rate comparison was used by X~2 (chi-square) test; the average comparison was used by T-test or analysis of variance, or using a rank test when variance missing, and correlation analysis was used by correlation and regression analysis. Level test was designated as a=0.05.ResultsTwo hundred and seventeen cases of liver cirrhosis with different syndromes were included in the study, among them 87 cases were Hp positive and 130 cases were negative, the Hp infection rate was 40.1%. those 217 cases were classified six syndromes: stagnation of liver-qi 20 cases, whose Hp infection rate was 3.7%; superabundance of dampness 41 cases, whose Hp infection rate was 7.4%; internal accumulation of damp-heat 86 cases, whose Hp infection rate was 15.2%; asthenia of liver and kidney yin 14cases, whose Hp infection rate was 2.8%; asthenia of spleen and kidney yang 25 cases, whose Hp infection rate was 4.1%; and blood stasis 31 cases, whose Hp infection rate was 6.9%. According to the liver function standard classification of Child-Pugh, Patients were divided into classA (57cases),classB (101cases) and classC (59cases). The Hp infection was no difference between each syndromes and no difference from Child-Pugh classification from A tO C the same (P>0.05). Among those 87 cases with Hp infection, the serum ammonia concentration was significantly higher than those patients without Hp infection (P<0.01). In Hp-positive group, the serum ammonia concentration in blood stasis syndrome patients was significantly higher than the other five syndromes (P<0.05) . between different Child-Pugh classification patients with Hp infection, the serum ammonia concentration of classification B and C was both significantly higher than classification A, Through The rank correlation analysis, the serum ammonia concentration was increased as Child—Pugh classification from A to C (P<0.05) .ConclusionsThere was close correlation between Hp infection and the serum ammonia concentration in Liver Cirrhosis patients. Hp infection is an important factor which caused serum ammonia concentration increasing in patients with liver cirrhosis. The serum ammonia concentration in blood stasis syndrome patients was significantly increasing, and the serum ammonia concentration was increased as Liver function get worse.