The Study Of The Relationships Between HPV Subtypes And Xinjiang Uygur And Han With Cervical Adenocarcinoma

Objective: To investigate the distribution differentions of subtypes of human papillomavirus (Human papilloma virus, HPV) between Xinjiang Uygur and Han women with cervical adenocarcinoma, provide basis for the prevention of adenocarcinoma of the cervix from Xinjiang. Method: To detect the 21 subtypes of HPV (including 13 kinds of high-risk subtype: 16,18,31,33,35,39,45,51,52,56,58,59,68;five kinds of low-risk subtypes: 6,11,42,43,44; three kinds of Chinese people common subtype of 53,66 and CP8304)from 100 cases of cervical adenocarcinoma(70 cases of Han,30 cases of Uygur),by using flow-through hybridization and gene chip technology. Results: ( 1 ) The positive rate of HPV in 100 cases of cervical adenocarcinoma (including single and multiple infections)was 61% (61/100),the positive rate of HPV in Han was 60% (42/70), while 63.3% (19/30)in Uygurs. There has no significant difference between two nations(P> 0.05)(.2)The distribution of HPV subtypes in the two nations are: HPV16 ratio was 90.4% of Han, followed by HPV18 (23.8%)and HPV68(4.7%),the ratio of HPV16 was 89.5% in Uygurs, followed by HPV18 (21% )and HPV68(10.5%),the subtypes of HPV have no significant differences two nations (P> 0.05)(.3)All specimens of 21 kinds of HPV subtypes were detected in five kinds ,16 species were not detected,there was no significant differences in single HPV infection and multiple infections between two groups(P> 0.05).(4)The positive rate of HPV in all patients have no significant difference between clinical stages.(5) There has significant difference between tumor size and The HPV infection rate. Conclusions: The cervical adenocarcinomas of both Uygur and Han were closely related to the HPV infection , in particular with HPV16 infection .The next common subtypes of HPV were HPV18 and HPV68. Xinjiang Uygur and Han women with cervical adenocarcinoma had the relatively higher risk of suffering HPV68 infection , this is different from other reports. The HPV infection has relations to tumor size ,but no relations to clinical stages of cervical adenocarcinoma.