A Randomized Controlled Study On Comparison Between Propofol And Fentanyl Inhibit Stress Responses In Tracheal Extubation

Objective To investigate the recovery after general anesthesia, tracheal extubation lifting by the process of hemodynamic fluctuations very common. Of this study was to explore propofol and fentanyl for tracheal extubation inhibit stress responses role. Methods We collected 60 ASA 1 ~ 2, and in the anesthesia recovery room (PACU) to tracheal extubation resumption of general anesthesia were randomly divided into four groups (n = 15): In the control group (groupâ… ), propofol group (groupâ…¡), fentanyl group (groupâ…¢), propofol and fentanyl (groupâ…£). Comparison of the four groups of patients without surgical operation, the four time points (extubation before extubation, extubation after 5 min, 10 min after extubation)in the blood pressure (BP), heart rate (HR), pulse oxygen saturation (SpO2), as well as three time points (extubation before extubation, 10 min after extubation) in the blood cortisol (Cor) changes. Results The four groups were comparable with respect to age, weight, preoperative ASA grade, systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), pulse oxygen saturation (SpO2). The change of SBP \ DBP relatively stable in Groupâ…¡, and propofol have a significant impact on DBP (P = 0.039); compared with the before extubation time point, the increase of HR in the 10 min time point was not significantly in groupâ…¢(P> 0.05), and fentanyl have a significant impact on Cor (P = 0.036) and HR (P = 0.015). A total of 43 patients (72.9%) had an adverse reaction, the most serious complications is respiratory depression. Conclusion Propofol can be used for postoperative extubation Wai blood pressure control, small dose of fentanyl can inhibit Wai extubation of the stress response. However, in order to obtain the best effect, we should be rational use of the muscle relaxant quantitative monitoring device (such as TOF), and monitor the level of consciousness (such as BIS or Entropy), to intervene in intravenous sedation analgesia drug dosage, delivery methods and delivery time, and to provide guidance to extubation.