Clinical Study Of 628 Hypertensives Whose Blood Pressure Were Difficult To Control

Objective To analyze the etiology, metabolic disorders and target organ damage of in-patients hypertensives whose blood pressure were difficult to control and to observe differences of metabolic disorders and target organ damage between essential hypertension(EH) and secondary hypertension(SH) in order to provide basis of correct diagnosis and therapy of these hyperensives. Methods Retrospective study was performed based on etiology, metabolic disorders and target organ damage of 628 in-patients hypertensives whose blood pressure were difficult to control in department of hypertension, People's Hospital of Xinjiang Uighur Autonomous Region, from September 1997 to December 2005. Comparison of metabolic disorders and target organ damage between EH and SH were performed. The datum were analyzed by using SPSS 13.0 software package. Results 1.Of 628 in-patients hypertensives whose blood pressure were difficult to control, there were 80.10% of EH, 18.95% of SH and 0.95% of indefinite diagnosis. 2.119 SH comprised 33.61% of renovascular hypertension, 15.97% of renal hypertension , 23.53 % of obstructive sleep apnea syndrome, 13.45% of primary aldosteronism, 5.04% of pheochromocytoma. 3. Of 628 in-patients hypertensives whose blood pressure were difficult to control, there were 66.24% of dyslipidemia, 43.78% of abnormality of glucose metabolism. Prevalence of diabetes mellitus (P<0.001)and level of body mass index(P<0.05) in essential hypertension were higher than those in secondary hypertension. 4. Of 628 in-patients hypertensives whose blood pressure were difficult to control, prevalence of stroke, coronary heart disease, chronic heart failure, chronic renal inadequacy were 39.97%, 31.85%, 16.57%, 29.62%, respectively. Prevalence of stroke, coronary heart disease and age in EH were higher than those in SH. Prevalence of chronic renal inadequacy and levels of blood pressure in SH were higher than those in EH. Conclusion EH was main composition in in-patients hypertensives whose blood pressure were difficult to control, renal and renovascular hypertension and obstructive sleep apnea syndrome were major cause of blood pressure difficult to control. Most hypertensives whose blood pressure was difficult to control complicated with metabolic disorders, there were severe target organ damage in those hypertensives. It play an important role on protection of target organ damage to make blood pressure control and rectify metabolic disorders.