Expression Of PTTG, C-myc And P53 Protein In Non-Small Cell Lung Carcinoma And Its Significance

Objective:To investigate the relationship between the expression of PTTG;c-myc and p53 and their role in occurrence and development of non-small cell lung carcinoma.Methods:The expression of PTTG,c-myc and p53 was detected immunohistochemistrically by EnVision^TMmethod in 60 cases of non-small cell lung carcinoma and 27 cases of normal lung tissue.Results:1.There was an extensive expression of PTTG and c- myc in nucleus and cytoplasm of tumor cell(P＜0.01),there was an extensive expression of p53 in nucleus of tumor cell(P＜0.01).They were also existed less in normal lung tissue.2.The positive rate of PTTG,c-myc and p53 was 73.33%,58.33% and 53.33%differencely in tumor cell and 11.11%,18.52%and 7.41% differencely in normal lung tissue.There was a significant difference between tumor cell and normal lung tissue.(X²=29.025,11.884,16.497; P=0.000,0.001,0.000).3.Difference was not found between the expression of PTTG and c-myc in age groups(X²=0.019,0.221,0.729;P=0.991,0.895,0.694)and gender groups(X²=0.057,0.286,0.011;P=0.812,0.593,0.916). Difference was also not found in groups of pathological tapes (X²=0.302,0.020,0.350;P=0.582,0.888,0.554)and tumor size (X²=0.073,0.264,0.550;P=0.964,0.876,0.760).4.The expression of PTTG and c-myc in tumor cell was both correlated with differentiated degree of NSCLC(X²=8.727,10.288;P= 0.013,0.006),the expression of p53 was not correlated with differentiated degree of NSCLC(X²=0.107,P=0.948)5.In NSCLC with lymph node metastasis,the positive rate of PTTG and c-myc was 89.29%,75.0%;and was 59.37%,39.29%respectively in groups without lymph node metastasis.There was a significant difference between the two groups(X²=6.832,16.194,P=0.009,0.000).The positive rate of p53 was 60.71%,and was 46.88%in groups without lymph node metastasis.There was not a significant difference between the two groups(P=0.284).6.The expression of PTTG and c-myc in non-small cell lung carcinoma had a striking positive correlation(rs=0.516,P＜0.01);PTTG and p53 in non-small cell lung carcinoma had a striking positive correlation(rs=0.418,P＜0.01);c-myc and p53 also had a striking positive correlation(rs=0.309,P＜0.05).Conclusion:1.The positive rate of PTTG,c-myc and p53 was higher than that in normal lung tissue indicated that all were participated in occurrence of NSCLC.2.Both PTTG and c-myc were correlated with differentiation of tumor cell and lymph node metastasis suggested they may involve in the development of NSCLC.3.The positive expression of PTTG,c-myc and PTTG,p53 in non-small cell lung carcinoma had a striking positive correlation respectively(P＜0.01),they were coordinated in occurrence and development of NSCLC.The positive expression of c-myc and p53 also had a striking positive correlation(P＜0.05),and they were coordinated in occurrence and development of NSCLC too.4.Detecting all of them would be beneficial to evaluating prognosis and the therapeutic guidance in NSCLC.