Epithelial-mesenchymal Transition Research Of Epidermal Stem Cell By The Inducement Of Melanoma Cell

Cancer stem cells (CSC) are recently proposed to be the cancer initiating cells responsible for tumorigenesis and contribute to cancer resistance. These studies suggest that CSC originates from that of normal stem cells, aberrant counterparts of normal stem cells.So, the stem cell hypothesis of cancer development were further proposed. However, several issues relating to this phenomenon as yet remain unaddressed. A fundamental question is one relating to the identification of events leading to transformation of a normal tissue stem cell to a cancer stem cell. To study whether or not normal stem cell can obtain malignant transformation in tumor microenvironment, we established a model in vitro for inducing malignant transformation of epidermal stem cell with a metastatic melanoma microenvironment to determine the possible epigenetic influence of this microenvironment on HEESC behavior. Specifically, our study tested the hypothesis that the microenvironment of metastatic melanoma cells could induce induce neoplastic transformation in human epithelial stem cell.