Evaluation Of Liver Reserve Function Pre-operation And Post-operation For The Patients With Primary Liver Carcinoma

Objective:To investigate retention rate of indocyanine green at fifteen minutes (ICGR₁₅) and effective hepatic blood flow(EHBF)to evaluate liver reserve function for the patients with primary liver carcinoma pre-operation and post-operation. Method: 55 patients with primary liver carcinoma were enrolled in this study. Before operation each patient was tested ICGR₁₅ and EHBF by pulse dye densitography analyzer(DDG). Based on the ICGR₁₅ all patients were divided into 3 groups:X group(ICGR₁₅<10%), Y group(ICGR₁₅ 10%～20%)and Z group(ICGR₁₅>20%), meanwhile the routine liver function and Child-Pugh classification were tested as well. After operation, all those patients were divided into three groups according to liver function conditions: group G(well-recovered group);group M(mild liver dysfunction group);group S(severe liver dysfunction group). The incidences of hepatic failure after operation among X,Y and Z groups and among different Child-Pugh classification ICGR₁₅ and EHBF were analyzed;routine liver function tests, Child-Pugh classification, ICGR₁₅, EHBF were also analyzed among G, M, S groups. Results: After operation, the incidences of liver dysfunction among X,Y and Z group were 9.5%, 45% and 71.4%, respectively(P<0.05), however, there were no differences in Child-Pugh Classification and routine liver function tests among G, M, S groups before operation, there were significantly differences in ICGR₁₅ and EHBF(P<0.05). Among different Child-Pugh classification, there were significantly differences in ICGR₁₅ and EHBF(P<0.05). Conclusion: The ICGR₁₅ and EHBF can be considered as indicators to evaluate the liver reserve function and more precise than Child-Pugh;meanwhile, the ICGR15 could be helpful in predicting the incidence of liver dysfunction for the patients with primary liver carcinoma.