| Objective:To discuss the variety and pertinence among the levels of insulin resistance,blood serum free fatty acid in subjects with Type 2 Diabetes after antidiatebes medication.Methods:54 patinents with Type 2 Diatebes had been treated with merformin and glipizid for 12 weeks,and we measured the fasting blood serum FFA,Leptin,insulin and blood glucose beforeand after treatments,and then calculated the HOMA-IR.The normal group was measured the same index,and processed statistic analyses.Results:â‘ The HOMA-IR,fasting blood serum concentrations of FFA,Leptin are higher than the normal group,even in subjects whose BMI and waistline was the same as normal.â‘¡The HOMA-IR and fasting FFA were improved distinctly, the differences showed statistic significance;fasting blood serum concentrations of Leptin was lower but without notable difference.â‘¢The concentrations of fasting blood serum FFA and Leptin were correlated with the HOMA-IR,but FFA had no relationship with Leptin.Conclusion:â‘ The concentrations of fasting blood serum free fatty acid and Leptin which were higher in Type 2 Diabetes subjects were correlated with the index of insulin resistance,and both important to insulin resistance.â‘¡The affections of free fatty acid and Leptin to insulin resisitance were independent of each other.â‘¢the decrease of free fatty acid contributed to the improvement of insulin resistance most after treatments. |
PDF Full Text Request