| The object of this study were patients with Parkinson's disease and health controls, T2RT in the dependency structure of PD and MRS were measured to understand the variations of cerebral metabolism in PD, hoping to offer an index for the diagnosis of PD.Part One: Quantitative measurement of T2RT of brain gray nucleusObjective: To quantitatively analyze the variations of brain iron in PD and choose the volume of interest for the MRS measurement, where the changes of magnetic field homogeneity were obsolete, by measuring T2RT of brain gray nucleus. Materials and methods:â‘ Choosing 20 health volunteers as control, T2RT were measured in both sides of CA, PM, GP and SNC to provide reference for T2RT in the PD brains;â‘¡T2RT were measured in both sides of CA, PM, GP and SNC in 17 PD patients. The T2RT of CA, PM, GP and SNC contralateral to the affected side were compared to those contralateral to the asymptomatic side, and also compared to those of controls respectively. Results:â‘ There were no significant difference in the T2RT of CA, PM, GP and SNC between two sides or sexes (independent-samples t-test, P>0.05);â‘¡The gray nucleus of T2RT from the lowest to the highest were GP, PM, SNC, CA;â‘¢T2RT decreased in SNC and increased in GP, when compared to the controls(Dunnett-t test, P<0.05). But there were no significant difference between the opposite side of affected extremities and those of asymptomatic extremities (two-sample t-test, P>0.05);â‘£The T2RT of PM contralateral to the affected side and those contralateral to the asymptomatic side were no significantly different (independent-samples t-test, P>0.05). Also, there were no significant difference, when compared to the controls (Dunnett t-test, P>0.05)Conclusions:â‘ MRI can be used to detect brain iron, T2RT can reflect the regional distribution of brain iron;â‘¡The T2RT decreased in SNC and increased in GP in PD patients, which reflected that iron increased in SNC and decreased in GP in PD patients. The quantitative measurement of T2RT can be used as an atraumatic method of PD diagnosis;â‘¢The T2RT were no significant difference in PM contralateral to the affected side, contralateral to the asymptomatic side and controds. It implied that the iron concentration were no significant difference. So the changes of magnetic field homogeneity were obsolete in PM, and PM could be chosen as the reasonable VOI for MRS measurement.Part Two: The preliminary study of MRS in PM in PD brainsObjective: To investigate the changes of NAA/Cr and Cho/Cr of PM in patients with PD by MRS analysis in both sides of PM. Materials and methods:â‘ Seventeen health volunteers were chosen as controls and underwent MRS scan in both sides of PM, which provided a reference for PD patients;â‘¡Seventeen patients with PD underwent MRS scan in both sides of PM. The results were compared within patients with PD and to the controls. Results:â‘ NAA/Cr and Cho/Cr of PM in controls were no significantly different between right-and-left sides or sexes(independent-samples t-test, P>0.05);â‘¡The Cho/Cr of PM contralateral to the affected side in patients of Hoehn-Yahr stageâ… and both sides in patients of Hoehn-Yahr stageâ…¡were higher than those in controls(Dunnett t-test, P<0.05). Also the Cho/Cr of PM contralateral to the affected side and those of contralateral to the asymptomatic side were no significantly different (independent-samples t-test, P>0.05). Conclusions: MRS could reflect the Cho/Cr changes of PM in patients with PD, so could provide an index for the diagnosis even early diagnosis of PD. |
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