Study On Cognitive Function And Cardiovascular Risk Factors In Central Obese Adolescents

Objectives To examinate the effect of central obesity on cognitive function, and toexplore the clustering of cardiovascular risk factors in central obese adolescents.Methods According to their informed consents, sixty-seven adolescents who camefrom middle school in Hefei and Maanshan respectively took part in our study. Theanthropometric indexes of height, weight, waist circumference (WC), hip circumferencetriceps, subscapular and abdominal skinfold thicknesses (SFs) were measured accordingto standard procedures. The defining of obese was used by body mass index (BMI), andthe central obesity was defined as waist-hip ratio (WHR)＞sex-age-specific P₉₀ cut-offpoint from data of students who were from the urban areas of Anhui province in theNational Survey on Students' Constitution and Health in 2005. The indexes of bodycomposition, neurochemical in frontal and hippocampus, P₃₀₀ latency were respectivelymeasured by dual-energy X-ray absorptiometry, ¹H-MRS, event-related potentials, andthe blood glucose and blood fat were both examined by blood chemical analysis. Weobtained the objects' hemodynamics parameters on common, the bulb or bifurcationareas, and internal carotid segments, aterior cerebral artery, middle cerebral artery,posterior cerebral artery, and the indexs of heart, which were all measured by colourB-mode ultrasonographic.Results The means of weight, BMI, WC, HC, WHR, SFs and percent body fat incentral obese group were significantly higher than those in controlled group (P＜0.05). The contents of NAA, NAA/Cr and Cho on ¹H-MRS reduced in central obese group (P＜0.05). In the analysis of covariance, the correct mean of P₃₀₀ latency in central obesegroup was longer than that in controlled group after body fat has being adjusted. TG inobese group was higher than that in overweight group, while HDL in obese group waslower than that in overweight group (P=0.02, 0.04). The indexes of aortic root innerdiameter, left atrium inner diameter, interventricular septum thickness mearused byDoppler in obese group also were significantly higher than those in overweight group (P＜0.05). In overweight group, Vd (depth 56mm) in middle cerebral artery, Vd (depth66mm) in aterior cerebral artery, and Vm (proximate depth 74mm,78mm and distantdepth 80mm), Vs (proximate depth 72mm), Vd (proximate depth 72mm, 74mm,76mm,78mm and distant depth 80mm) in basilar artery were all significantly higherthan those in central obese group. In central obese group, PI (depth 54mm) in middlecerebral artery, PI (depth 66mm and 68mm), RI (depth 66mm) in aterior cerebral artery,PI (proximate depth 74mm and distant depth 80mm), RI (proximate depth 74mm,76mm and distant depth 80mm) in basilar artery, PI (left depth 60 mm), RI (left depth60 mm) in vertebral artery were significantly higher than those in overweight group.It was shown that the indexes of left common carotid artery (CCA) diameter andintima-media thickness, the right CCA intima-media thickness, PI and RI, the rightinternal carotid artery (ICA) diameter and intima-media in obese group significantlyhigher than those in overweight group (P＜0.05). But in obese group, the indexes ofLeft CCA Vs and Vd, the bifurcation areas of right carotid segments Vd weresignificantly lower than those in overweight group (P＜0.05).Conclusions Central obesity might impact on the process of brain metabolism, andprolonged the cognitive processing in adolescents. Cardiovascular risk factors mightcluster in central obese adolescents.