The Function Of The Carcinoembryonic Antigen On Early Recurrence Of Non-small Cell Lung Cancer

Objective: To explore clinical and pathological factors correlating with early recurrence of resected non- small cell lung cancer (NSCLC), and to further understand the function of carcinoembryonic antigen (CEA) on NSCLC.Methods: 66 patients of NSCLC were selected. All of them received resection and were followed up for one year. The time of first recurrence was recorded. Logistic univariate and multivariable analysis were used to find the factors that affect the early recurrence of NSLSC, including age, sex, serum CEA level, tumor size, tumor differentiation, histological type, clinical staging and molecular staging; The ability of factors predicting the recurrence were compared by receiver operating characteristic (ROC) curve. And then, Logistic univariate and multivariable analysis were used to find the factors that affect the lymph node micrometastasis of NSLSC, and the ability of factors predicting lymph node micrometastasis were compared by ROC curve.Results: 1. Of all the clinical and pathological factors that are correlated with early recurrence of NSCLC, the serum CEA value, clinical staging, and molecular staging are of statistical significance. The preoperative serum CEA value is the most valuable factor to predict early recurrence of NSCLC (ROC area: 0.905, 95% CI: 0.831～0.997, P＜0.05). When preoperative serum CEA value＞5μg/L, patients of NSCLC will have an early recurrence rate of 93.8 %; and when preoperative serum CEA value =5μg/L, the probability of no early recurrence is 70 %. 2. The serum CEA value, and clinical staging are of statistical significance that are correlated with lymph node micrometastasis of NSCLC. The preoperative serum CEA value (ROC area: 0.882, 95%CI:0.703～0.941, P＜0.05) and clinical staging (ROC area: 0.845, 95%CI: 0.713～0.978, P＜0.05) are valuable factors to predict lymph node micrometastasis of NSCLC.Conclusion: For the patients with respectable NSCLC, it is very important to know the precise clinical stage and molecular stage, and so is the preoperative serum CEA value. The preoperative serum CEA value and clinical stage are valuable factors to predict lymph node micrometastasis of NSCLC. When preoperative serum CEA value＞5μg/L, even if the lesion is of early stage and well differenced, the general situation of patients should be carefully examined for the prompt and accurate treatment to them and close follow up is needed to treat these patients.