A Study On The Relationship Between Sleep-disordered Breathing And Acute Stroke

Aim: To determine the prevalence and course of sleep-disordered breathing inacute stroke inpatients,and its relation to age, BMI, Neck circumference, EpworthSleepiness Scale, History of hypertension, Diabetes mellitus, Previous stroke/TIA,Smoking, Habitual snoring, Barthel index Score, SNSS and post-strokeoutcome.Further studywas to redefine respiratory events and to assess their impact on outcome.Methods: Paired respiratory sleep studies were performed at week1 and week 12—14 following stroke. Pre-and post-stroke handicap, at week 1 andweek 12-14disability (Barthel index Score) and impairment (ScandinavianNeurological Stroke Score) were assessed. Pre-stroke sleepiness was determined byEpworth Score. Each patient wassubsequently followed up at 4 months to determine mortality.Results: There were 120 patients in the week 1 and in the week6-8 study. Male is 87.96％, female is 12.15％. RDI《5 is 59.2％, RDI5-20 is 59.2％,RDI》20 is 3.3％. The oldest is 102 years-old, The youngestis 40 years-old, Mean is 67.67±8.94, snore is 60.8％. Coronary artery cardiopathyis 84.2％, hypertension is 69.2％, diabetes mellitus is 56.70％,Hypercholesterolemia is 45％. RDI is relation to BMI (R=0.252 P=0.005), Neckcircumference (R=0.254 P=0.005), Epworth Sleepiness Scale (R=0.766P=0.000), History of hypertension (R=0.197 P=0.031), snore (R=0.296P=0.001), Pre-stroke sleepiness was associated with post-stroke neurologicalimpairment(R=-0.302 P=0.001) and disability(r=0.112 P=0.224). The Barthel index was independently relation to minimumoxygen saturation during the night (β=0.273 p=0.010 ).Discussion: Sleep-disordered breathing following stroke have highly prevalent.The severity of sleep-disordered breathing appears to be associated with age,BMI, Neck circumference, Epworth Sleepiness Scale, History of hypertension and aworse functional outcome following stroke, increasing the likelihood of death anddependency. Longer respiratory events appear to have a greater effect. These datasuggest that long term outcome might be improved by reducing sleep-disorderedbreathing in acute stroke.