Study On The Effects Of Acute Alcohol Intake On HRV, Pd And QTd In Healthy Men

Objectives: Alcohol has been drinking as a beverage for severalthousand years, its effect on human health has been recognized gradually.The nerve system and the body fluid play on important part in the acutealcohol ingestion induced effects. At present, the heart rate variabilityhas been a better kind of noninvasive technology, which can generallyappraise the tension and balance of autonomic nerve activity. Thisarticle will study how acute drinking affect on autonomic nerve whichwill be appraised by a quantitative index of HRV.Methods: 14 healthy male volunteers recruited for this study had twotimes dines seperately for one week interval. They consumed ethanol 1g/kgbody weight with a meal on the first time; on the second meal they consumedthe same amount of juice with the same kind of meal. It was drawn justat rest and one hour after the meal to assay the blood alcohol andcatecholamine. At the same time 20 minutes Holter recording was performed,and heart rate and blood pressure were measured. Indices of HRV werecalculated with frequency domain methods.Results: In comparison with baseline and juice drinking, bloodalcohol concentration, adrenalineand noradrenaline values of 1 hourafter alcohol were significantly increased (P＜0.01, P＜0.01, P＜0.01); systolic pressure, diastolic pressure and heart rate had nodifferences(P=-0.52, P=-0.15, P=0.12)among them. HF, LF, and TF, the indicesof 1 hour after alcohol ingestion were significantly decreased (P＜0.01,P＜0.01, P＜0.01), but LF/HFwas increased significantly (P=0.024) incomparison with baseline and juice drinking. HF, LF, TF and LF/HF had nodifferences between baseline and juice (P=-0.89, P=-0.15, P=-0.64, P=-0.84). Conclusion: While blood alcohol concentration, adrenaline andnoradrenaline were all increased significantly after one hour of acutealcohol intake, the indices of HRV was decreased, which means that thevagal activity was reduced, sympathesis nerve was excited, and then thebalance of autonomic nerve activity was destroyed, but the effects ofalcohol on heart rate and blood pressure were not obvious. Objectives: P wave dispersion(Pd), defined as the difference betweenthe maximum and the minimum P wave duration on the 12 lead electrocardiogram, and maximum P wave duration are electrocardiographic markersthat have been used to evaluate the inhomogeneous intraatrial andinteratrial conduction. The association between Pd and acute alcoholintake has rarely been studied in normal subjects. QT dispersion (QTd)is the maximal interlead difference in the QT interval on the surface12-lead electrocardiograph. An increased in QTd is found in patientswith various cardiac diseases. Variability of QT duration among the 12surface ECG leads expresses electrical instability and greatersusceptibility tomaglignant ventricular arrhythmias. Previous studieshave shown that episodic drinking facilitates the induction ofventricular tachyarrhythmias in some drinkers. Present article will studythe effects of acute alcohol on Pd and QTd.Methods: There were 14 healthy male volunteers recruited for thisstudy, had two times dines seperately for one week interval. For the firstmeal each subject consumed 1g/kg body weight ethanol while eating; thesecond meal consumed the same amount of juice and ate the same kind ofmeal. Blood alcohol concentration, catecholamine were assayed just atrest and after 1 hour of the meal. At the same time electrocardiogramwere recorded and so did heart rate and blood pressure. Pd and QTdmeasurements were performed manually and blindly by two medicallyqualified investigators.Results: In comparison with baseline and juice drinking, blood alcoholconcentration, adrenaline and noradrenaline values after 1 hour of alcohol drinking were significantly increased (P＜0.01, P＜0.01, P＜0.01); systolic pressure, diastolic pressure and heart rate had nodiferences (P＞0.05, P＞0.05, P＞0.05). Pmax, Pd and QTmax, QTd 1 hourafter alcohol ingestionwere significantly increased (P＜0.05, P＜0.01,P＜0.05, P＜0.01), but Pmin and QTmin have no differences with baselineand juice drinking (P＞0.05, P＞0.05).Conclusion: Acute moderate dose of alcohol intake in short time isassociated with an inc, rease in Pmax, Pd and QTmax, QTd.