The Effects Of Anaesthesia With Inhaled Sevoflurane Or Isoflurane On Coagulation In Patients Undergoing Breast Cancer Radical Surgery

Objective: Previous studies have reported sevoflurane had significant inhibitoryeffect on platelet aggregation, and prolonged bleeding time in humans. However, theinfluence of sevoflurane on whole blood coagulation in vivo has not been elucidatedso far. In the present study the parameters of conventional coagulation andthrombelastographic tests were compared during sevoflurane and isofluraneanesthesia in patients who undergo radical surgery of breast cancer.Methods: Thirty ASAⅠ～Ⅱpatients scheduled for elective breast radical operationwere divided into two groups(n=15 each). Premedication and induction of anesthesiawere identical. Anesthesia was induced with fentanyl, midazolam, propofol,atracurium intravenously and maintained with sevoflurane in the first, isoflurane inthe second group at end-tidal concentration 1 MAC. Thrombelastographic tests onwhole blood was performed in the operating room pre-induction (T₀) andimmediatedly after the surgery (T₁) in both groups. In addition, conventionalcoagulation parameters such as PT, APTT, TT, fibrinogen concentrations (FIB), thetimes of operation and anesthesia were recorded.Results: There were no significant differences in thrombelastographic coagulationvariables (R-time, K-time,αangle, MA and CL30) or conventional coagulationparameters (PT, APTT, TT, FIB) at two time points between two groupsrespectively(P＞0.05).Conclusion: In our study, sevoflurane anaesthesia did not alter significantly anymeasured coagulation parameters in patients who undergo breast cancer surgery whencompared to inhaled isoflurane.