Study On Bacterial Colonization And Correlating Factors On Premature Infants In NICU

Objective: The danger factors of bacterial planting increase greatly in the prematureinfants, especially-extremely low and ultra-low birth weight infants because of their lowimmune functions, lacking of anti-bacterial planting capacity, additionally longer hospitalstay and more invasive examination and treatment. In addition, the use of broad-spectrum antibiotic on the premature infants result in bacterials drug resistance easily.Moreover, the worse condition which has been found is that there is no reliable iatricalmedicine of bacteria drug resistance. The great problems which NICU is facing to are theinfection caused by bacterial planting and bacterial drug resistance. The paper detectedbacterial planting and the drug resistance of bacterial planting drug on premature infants inNICU.Methods: Bacteriological monitoring was performed on the premature infants who weretreated in the ward of infants' serious illness in Beijing HuaXin hospital between January2006 and August 2006. Conventional throat swab and intestinum swab were done once aweek since they entered the hospital. Clinical and laboratory datas of every prematureinfant were collected, then the results were analyzed statistically.Result: 156 bacterial plantings were cultivated from the 49 premature infants in all,among which 79 ESBLs were produced. There were six cases of bacterial planting on theday when the infant entered the hospital, most of which(62.8％) were gram-negativebacillus, such as Klebsiella pneumonia subspecies and Escherichia coli, which are drug-fastto broad-spectrumβlactams. Meropenem and imipenem were the most sensitiveantibiotics being used currently to the gram-negative bacillus. Gram-positive coccus weresensitive to the vancomycin and teicoplanin.Conclusion: Bacteriological monitoring is rather necessary to the NICU hospitalizedpremature infants, then we can estimate the state of the bacterial planting according to theresults of monitoring and take protective measures in time. Moreover, we should selectsensitive antibiotics to control the infections of premature infants.