Expressions Of MT1-MMP, MMP-2 And HPSE In Pancreatic Carcinoma And Their Relationship With Perineural Invasion, Metastasis And Prognosis

Objective To investigate the expression of MT1-MMP, MMP-2 and HPSE inpancreatic carcinoma and their relationship with perineural invasion, metastasis andprognosis. Methods Immunohistochemical double-stainning technique was used todetect the expression of MT1-MMP, MMP-2 and HPSE in 47 cases of pancreaticcarcinoma, and the nerve-fiber was stained by s-100. To observe the relationship betweenthe positive rates of these three markers expression and perineural invasion, metastasisand prognosis. Results (1) The positive rates of MT1-MMP, MMP-2 and HPSEexpression in patients with pancreatic carcinoma associated with perineural invasionwere higher than that without perineural invasion (x~2=4.240, 11.5741, 9.935; P＜0.05);(2) The positive expression rates of MT1-MMP, MMP-2 and HPSE were significantlyrelated to the metastasis, clinical stage and prognosis (P＜0.01), but they did notcorrelated with sex, age and tumor size (P＞0.05); (3) The positive rate of HPSEexpression in pancreatic carcinoma was related to histological grade (x~2=7.748, P＜0.05),but the expressions of MT1-MMP, MMP-2 were not correlated with it (x~2=1.625, 1.382;P＞0.05); (4)There was a positive correlationship between the expression of MT1-MMPand MMP-2 (r=0.585, P＜0.01). Conclusions (1) The expression of MT1-MMP, MMP-2 and HPSE in pancreatic carcinoma may be responsible for PNI and metastasis,and their positive rates are closely correlated with distant metastasis, clinical stage andprognosis; (2) The pancreatic carcinoma cells, some of vescular endothelial cells andfibroblasts in the extracellular matrix of tumor tissues can express MT1-MMP, MMP-2and HPSE, and promote the invasion of pancreatic carcinoma.; (3) Detecting theexpressions of MT1-MMP, MMP-2 and HPSE in pancreatic carcinoma might play animportant role in demonstrating the biological behavior of pancreatic carcinoma.