The Expression And The Value Of Metallthionein In Transitional Cell Carcinoma Of Bladder

Objectives: To study the expression of MT protein in the bladder transitional cell carcinoma(BTCC), to evaluate the relation of the MT protein with different histological grades and clinical stages in in the bladder transaitional cell carcinoma, and to expect it to have a significant value in early diagnosis and determining prognosis.Methods: The expression of MT and MMP-9 was dectected by the S-P(streptavidin-peroxidase) immunohistochemical method in 42 cases with bladder transitional cell carcinoma and 6 cases with nomal bladder tissue from June 2006 to December 2006 in the First Affiliated hospital of Kunming Medical college. The relationship between MT expression and various clinicopathological parameters including pathological grades and clinical stages was analyzed and the correlation between MT expression and MMP-9 expression was also analyzed.Results: Immuohistochemicaly, over-expression of MT was frequently (29 of 42 cases , 69．04%) detected in BTCC ,whereas no MT expression in the 6 nomal bladder tissues. MT expression was significantly associated with invasive bladder tissues. MMP-9 expression was also significantly associated with invasive bladder cancer (Tis-T₁ versus T₂-T₄, P<0．05) and with increased pathological grade .There was a significantly correlation between the expressiones of MT protein and MMP-9 protein (r= 0．351,P <0．05) .Conclusions: Expression of MT protein is closely correlated to invasion of BTCC. MT may play a critical role in occurrence and development of bladder transitional cell carcinoma, and MT has a intimate relationship with MMP-9 immuohistochemicaly...