Protective Effects Of Ulilastatin On Heart After Cardiopulmonary Resuscitation In Rabbits

Objective To investigate the cardiac dysfunction induced by cardiopulmonary resuscitation after cardiac arrest and the mechanism of protective effects of ulinastatin (UTI).Methods After setting up cardiopulmonary resuscitation model in rabbits, 30 animals were randomly devided into operation-control group (group S, n=10),routine resuscitation group(group C, n=10) and UTI treated group (group U, n=10). Group S was not induced cardiac arrest. Group C was performed standard CPR after cardiac arrest. Group U were group C + UTI.Dynamic observation of levels of left ventricular end diasto- lic pressure (LVEDP), maximal rate of increase and decrease in left ventricular pressure (±dp/dt) and levels of serum creatine kinase (CK) and MB isoenzyme of creatine kinase (CK-MB) were performed. The left ventricles of the rabbits were obtained for light and electronic microscopic observation.Results Contrast to group S, LVEDP CK and CK-MB in other groups gradually increased respectively (P<0. 01), and±dp/dt decreased (P<0. 01). Increases of LVEDP CK and CK-MB in group U were less than in group C (P<0. 05, P<0. 01), whereas±dp/dt was higher in group U than in group C at the same stage (P<0. 05). Myocardium were injuried in groups C and U and there were less myocardial injuries in UTI-treated groups than in group C at the same stage as shown with light and electronic microscopic observation.Conclusions UTI alleviates cardiac dysfunction and myocardial injury after cardiopulmonary resuscitation.