A Study Of The Association Of Leptin With The Expressions Of Complement Regulatory Protein CD55, CD59 In Patients With Hyperlipidemia

Objective To investigate the relationship between plasma leptin and the expresson of complement regulatory proteins CD55, CD59 in hyperlipidemia.Methods Fifty-eight, patients with hyperlipidemia were selected in this study and twenty one age-,sex-,height-, and body weight-matched healthy volunteers served as controls. Plasma leptin was examined with enzyme-linked immunosorbent assay (ELISA) and the expressions of CD55, CD59 on leucocytes were evaluated with flowcyometry.Results Compared with healthy controls, plasma level of leptin was significantly increased (M: 8357pg/ml vs 5348pg/ml, P=0.024) ,while the mean fluorescence intensity(MFI) and the percentage of CD55-positive lymphocytes were markedly decreased [(2.07±0.26) vs (2.34±0.44) and (35.72±13.53)%vs (44,14±15.67) %, P=0.012 and 0.022]. Leptin was positively correlated with total cholesterol, LDL-C, triglyceride, Body Mass Index, waist circumference and hip circumference (r=0.285～0.451, P=0.011～0.000) but not with the expressions of CD55 and CD59 (P>0.05).Conclusion Plasm leptin was increased while the expression of complement regulatory protein CD55 was decreased in hyperlipidemic patient. Leptin has no direct association with the expression of complement regulatory protein CD55 and CD59.