The Deficits In Prepulse Inhibition Of CPLX || Knockout Mice In Repeated Neonatal Isolation Stress

1. ObjectivesThe aim of this study was to investigate the change of sensorimotor gating of CPLX‖knockout mice in repeated neonatal isolation stress.2. MethodsThe mice were randomly divided into 4 groups: groups of CPLX‖-/- with stress, groups of wild type with stress, groups of CPLX‖-/- without stress and groups of wild type without stress. Isolation stress was employed on the pups of stress groups from the 2d day after the postnatal to the 21st day. Genotypes were confirmed using allele specific polymerase chain reaction with tail tips of mice at 4 weeks of age. The sensorimotor gating of mice was evaluated using prepulse inhibition at 50-55 days of age. Data were expressed as the mean±standard error of mean (SEM).The statistical significance of the data was evaluated using two-way ANOVAs and one-way ANOVA by SPSS 11.0 software. Difference was considered statistically significant if P values were less than 0.05.3.Results(1)The significant decrease in the prepulse inhibition observed in the knockout mouse and wild-type mouse regardless with maternal deprivation stress.(2) Prominent in the knockout mouse with maternal deprivation stress.