The Study On The Dielectric Property Of Unloaded Atrophied Skeletal Muscles From Rats

The dielectric study method of cells is to get the dielectric properties by the measurement of AC impedance. In this paper, we measured the dielectric spectrum of both normal and unloaded atrophied rat skeletal muscle fibers in the parallel orientation to the applied electric field by Agilent 4294A Impedance Analyzer in the frequency range of 40Hz-110MHz.The main contents of the research reads as follows:1. The dielectric spectrum of normal and unloaded atrophied rat skeletal muscle fibers were made in the wide frequency range .2. The dielectric spectrum, the Cole-Cole plots, the frequency spectrum of the dielectric loss factor and loss tangent were analyzed synthetically, then the dielectric numerical characters of rat skeletal muscle fibers were established.3. The math model of rat skeletal muscles was established by non-linear value accounting and curve fitting with Cole-Cole formula.4. The difference between the dielectric spectrum of both normal and atrophied rat skeletal muscle fibers were compared and analyzed.The results showed that :1. The dielectric response of rat skeletal muscle fibers have a dependence of frequency: with the increase of frequency, the permittivity decreases, while the conductivity trends to rise;2. The Cole-Cole math model can be meet by the dielectric response of rat skeletal muscle fibers;3. The dielectric response of atrophied rat skeletal muscle fibers differ from that of normal skeletal muscle fibers:1) At low frequencies : relative permittivityεL of atrophied skeletal muscle fibers decreased , and conductivityκL increased slightly ,while at higher frequencies : relative permittivityεh rised a little , conductivityκh reduced ; 2) Both relative permittivity incrementΔεand conductivity incrementΔκdecreased as compared with that of the normal skeletal muscle fibers , that is ,both insulation and conduction of unloaded atrophied skeletal muscle fibers reduced ;3) The dielectric loss factorΔε"and loss tangentΔtgδof atrophied skeletal muscle fibers reduced ;4) As compared with normal rat skeletal muscle fibers , the first characteristic frequency fC1 decreased , while the second characteristic frequency fC2 increased. moreover ,both the first characteristic frequency fC1 and the second characteristic frequency fC2 of whether normal or atrophied skeletal muscle fibers all differ from those of frog skeletal muscle fibers .We studied the passive electric characteristics of normal and unloaded atrophied rat skeletal muscle fibers, and explicated it's reflect, then we established the the math model , which have bottomed for the clinic diagnosis of atrophied skeletal muscle and for the study of new apparatus.Our research have important theoretic worth and learning sense.