Expression Of Platelet-derived Growth Factor AA In Rat Periodontal Tissues During Orthodontic Tooth Movement.

Objective: To observe the expression and distribution of platelet-derived growth factor AA in the periapex during experimental tooth movement , and analyze the role of PDGF-AA in orthodontic tooth movement, so that we could make more realization about the variety of orthodontic teeth movement. In order to provide reference support for oral clinic employment.Methods: Orthodontic appliances was placed between the maxillary right firstmolars and maxillary central incisors of adult Wistar rat. Immunohistochemical and image analyses were performed at 0,1,7,14,21 days after orthodontic force application.Results: The expression of PDGF-AA in the experimental groups enhance aply compared with that in the control group. 1 day after the experimental movement, the expression of PDGF-AA. On 7 day, it reached peak level. PDGF-AA was expressed in fibroblasts, osteoblasts and vascular endothelial cell.Conclusion: PDGF-AA participate in the periapex. remodeling of orthodontic tooth movement. can promote bone formation.