Study On Risk Factors For Psoriasis

Psoriasis is an inflammatory skin disease of unknown etiology. Genetic factor isone of the pathogenesis of this disease. However, environmental factors also playimportant roles in psoriasis, such as stress, infection, trauma, smoking, alcohol and soon. This study used epidemiological methods to explore risk factors for psoriasis. First,a case-control study on risk factors for Psoriasis was performed. The case-controlstudy conducted at Tianjin Changzheng Hospital. Data for 318 diagnosed cases and320 controls were randomly collected by questionare. Chi-square test, T- test andunconditional logistic regression model were performed by SPSS12.0 for statisticalanalysis.①Single factor analysis shows that age, profession, allergies, family history,concomitant diseases, infections, mental factors, moisture, contact history, traumahistory, smoking, alcohol, and food factors were correlated with psoriasis, and thedifferences were statistically significant (P＜0.05), suggesting that these factors wererisk factors for psoriasis; There were no significant between sex, nation, culture,marriage or vaccination history and psoriasis;②The multivariate logistic regressionanalysis results as following: family history, concomitant diseases, infections, mentalfactors, moisture, contact history, smoking and food factors were associate withsignificant risk factors for psoriasis(P＜0.05), suggesting that these factors were asindependent risk factors for psoriasis.Next we performed System review: Psoriasis and smoking or alcohol. A total of22 original studies met inclusion criteria. Meta-analysis was performed by RevMan4.2.Smoking was associate with a significant risk factor for psoriasis (OR=1.82, 95％CI1.63 to 2.03); there was significant between alcohol and psoriasis with (OR=2.32,95％CI 1.87 to 2.89). Subgroup analysis according to sex confirmed that smoking wasa risk factor for psoriasis (male OR=1.93, 95％CI 1.34 to 2.77; female OR=1.63,95％CI 1.30 to 2.03), and alcohol was also a risk factor for psoriasis (male OR=3.76,95％CI3.04 to 4.62; female OR=3.63, 95％CI 2.20 to 6.00). In conclusion, a case-control study confirmed that age, profession, allergies, familyhistory, concomitant diseases, infections, mental factors, moisture, contact history,trauma history, smoking, alcohol and food factors were risk factors for psoriasis.Family history, concomitant diseases, infections, mental factors, moisture, contacthistory, smoking and food factors were correlated with psoriasis, suggesting that thesefactors were as independent risk factors for psoriasis patients. System reviewconfirmed that smoking and alcohol were risk factors for psoriasis, without sexdifference. The study on risk factors for psoriasis was more comprehensive. The aimof the study was to advise psoriasis patients reducing the exposure risk factors, toextend remission, and to provide scientific reference for the prevention of psoriasis.