| Objective: By measuring sodium diuresis in patients with severe head injury factor-atrial natriuretic peptide (ANP) Brain natriuretic peptide (BNP) were clearly diuretic natriuretic facto in the severe brain injury hyponatremia, with cerebral salt wasting syndrome (CSWS), and for clinical type of hyponatremia after brain injury. treatment methods and theories to reduce mortality and morbidity of severe brain injuryMethods: grouping and Determination:Determination of 96 cases of patients with severe traumatic brain injury patients injured in the morning three days 7 days of fasting serum ANP, BNP, ADH, hematuria sodium, osmolality hematuria content. And central venous pressure measurement. Blood admission supine position adopted cubital vein with 3 mL, Home 10%EDTA containing 30μg L aprotinin, and 50μL of plastic centrifuge tube, the blender, then centrifuged (4°C, 3000 r/min,15 min), 500μL plasma, the ratio of -20℃home. RIA Detection using plasma ANP concentrations and ADH; The ELISA method BNP, Measuring hematuria conventional sodium, osmolality hematuria. And central venous pressure measurement. A serum sodium level under its "135mmol/L experimental group," 135mmol/L control group ANP and BNP ADH have observed no difference whether hyponatremia associated with the analysis. X±'s statistical data analysis, ADH then hyponatremia patient a experimental group (ADH<14 valus) the control group (ADH >14 valus) statistical analysis of two diuretic natriuretic factor, the biochemical markers is different..Results: first results 1 Patients in the experimental group 3 days (hyponatremia <135 mmol/L) 66, ANP : 302.41±19.4 valus the control group (hyponatremia>135 mmol/L) 30 : ANP 262±14.4. there was a difference. experimental group was significantly higher (P <0.05). and the normal group , the experimental group than in the normal (P <0.05). normal control group with no statistical significance(P>0.05). ANP statistical correlation with hyponatremia was negatively correlated. Hyponatremia is the higher the lower the value of ANPBNP : 133.40±5.54 valus experimental group. 96.55±5.54 valus differences between the two groups in the control group. experimental group was significantly higher (P <0.05 ). Compared with the normal group. experimental group than in the normal (P <0.01). Compared with normal control group were not statistically significant(P>0.05). BNP made with hyponatremia related statistics were negatively correlated. that is, the higher the value of BNP hyponatremia lowerADH : 23.18±0.63 valus experimental group. 15.23±0.56 valus control group differences in the two groups. experimental group was significantly higher (P <0.05 ). Compared with the normal group. experimental group than in the normal (P <0.05). Compared with normal control group were not statistically significant(P>0.05).2 Patients in the experimental group 7 days (hyponatremia <135 mmol/L) 66, ANP : 322.41±13.4Pg/ml. the control group (hyponatremia > 135 mmol/L) 30 : ANP 222±12.4. there was a difference. experimental group was significantly higher (P <0.01). and the normal group , experimental group than in the normal (P <0.01). and the normal control group were not statistically significant. ANP correlation with hyponatremia statistics were negatively correlated. ANP is the higher the lower the value of hyponatremiaBNP : 153.40±4.64 valus experimental group. 76.55±3.54 valus control group differences in the two groups. experimental group was significantly higher (P <0.01 ). Compared with the normal group. experimental group than in the normal (P <0.01). Compared with normal control group with no significant hyponatremia corresponding BNP Customs statistics were negatively correlated. that is, the higher the value of BNP hyponatremia lower.ADH : 22.23±0.74 valus experimental group. 12.23±0.34 valus control group differences in the two groups. experimental group was significantly higher (P<0.01 ). Compared with the normal group. experimental group than in the normal (P <0.05). Compared with normal control group were not statistically significant(P>0.05).the second step stat Results 1 3days in patients with hyponatremia experimental group (ADH<14 valus) 43, the control group (ADH >14 valus), 23 cases of ANP. BNP experimental group were significantly higher (P <0.01), ADH contrary, the experimental group than the control group. Hematuria than two biochemical markers of sodium and urine osmolality were not statistically significant(P>0.05). Osmotic blood test group (P <0.05). CVP experimental group than the control group (P <0.01)2. hyponatremia patients in the experimental group of seven days (ADH<14 valus) 43, the control group (ADH >14 valus), 23 cases of ANP. BNP experimental group were significantly higher (P <0.01), ADH contrary, the experimental group than the control group. Hematuria than two biochemical markers sodium, osmolality hematuria without statistical significance. CVP is still lower than that of the control group (P <0.05)Conclusion:1 diuretic natriuretic factor diuretic natriuretic factor-atrial natriuretic peptide (ANP) Brain natriuretic peptide (BNP) and brain injury also was negatively correlated with hyponatremia the two diuretic natriuretic factor diuretic 2 natriuretic factor -- -- atrial natriuretic peptide (ANP) Brain natriuretic peptide (BNP) and urea ADH-li hyponatremia in the formation of brain injury after a certain antagonism against then 3 diuretic natriuretic factor-atrial natriuretic peptide (ANP) Brain natriuretic peptide (BNP) is secreted abnormal cerebral salt wasting syndrome (CSWS) in the pathogenesis of important factors. 4 diuretic natriuretic factor-atrial natriuretic peptide (ANP) Brain natriuretic peptide (BNP) can be classified as hyponatremia after brain injury, treatment methods, theoretical basis。... |
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