| Objective 1. To investigate the risk factors related to diabetic peripheral neuropathy(DPN); 2. To explore the relations between DPN and Ankle-Brachial Index (ABI) ;3. To study diabetic foot ulceration and its risk factors in diabetic patients.Methods Total of 383 diabetic patients were investigated for DPN based on electrophysiological test including sensory or/and motor nerve conduction velocity (SNCV or/and MNCV). The related risk factors for DPN were analyzed. Case analysis study was carried out to assess the general clinical data and foot conditions related to diabetic foot ulceration in 383 patients with diabetes mellitus.Results The prevalence of DPN in admitted diabetic patients was 59.0%.In multivariate analysis, age, BMI,ABI, HbA1C and 24-h urinary albumin excretion , serum creatinine levels, BUN, two hours post C-peptide, duration of diabetes were the main covariates for the development of DPN. There was only 69.5% patients have neuropathy symptoms. Logistic regression analysis showed ABI, HbA1C duration of DM were related to DPN. The presence of DPN also correlated with presence of diabetic retinopathy (DR) and diabetic nephropathy (DN). The first significant change of NCV was observed when ABI≤1.1 (P<0.05). Significant changes were observed in all NCV when ABI≤0.9(P<0.05).The same changes happened when ABI≤0.8 except the age, HbA1C and duration of DM. These patients were predicted the risk of foot ulcers by Gavin's Scale. In 383 patients, 56.0%, 40.0% and 4.0% were in low-risk , moderate-risk and high-risk for foot ulcers respectively.Conclusions Low Ankle-Brachial Index(ABI≤0.9), the duration of DM, HbA1C are risk factors for diabetic peripheral neuropathy (DPN) . Nerve conduction velocity test is a sensitive, objective, and targeted measure for peripheral neuropathy .Foot conditions were poor in type 2 diabetic patients. In this study, 40.0% of the patients were at moderate risk of diabetic foot ulceration. |
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