| Objective: The study aim was to determine the predictive value ofcycle day 2 anti-Müllerian hormone (AMH/MIS) in predicting ovarianresponse.Methods: A total of 80 infertile women who had undergone the firstIVF-ET was studied prospectively. On cycle day 2, serum levels ofAMH, E2, FSH, LH, T and PRL were measured, and AFC estimated atultrasound scanning. Recording age, the number of retrieved oocytes,mature oocytes and high quality embryos et al.According to theirresponse to ovary sitmulation, the patients were classified into 2 groupsincluding (1)low response: the oocytes retrieved were or less 5,(2)normalresponse: the oocytes retrieved were more than 5.All the data wereanalysed by software engineering SPSS11.5.Results: 1. Median serum AMH levels in the low and normalresponse were(0.38±0.27ng/mL VS 2.10±1.25 ng/mL),Mean AMHlevels were statistically significantly different in each group. 2. Linearcorrelation analysis shows that the oocytes retrieved was positivelycorrelated to basal AMH level and AFC (r=0.776,r=0.577); Whilenegatively correlated to basal FSH level and FSH/LH (r=-0.405,r=-0.528).3.Multivariate regression analysis demonstrated that day 2 serum AMHhad the greatest independ contribution in number of retrieved oocytes, then was AFC,FSH,FSH/LH and age. 4.The AMH's ROCAuc is 0.961.Conclusions: 1. day 2 serum AMH/MIS level is better predictors ofovarian response than other currently available markers in ART.2When0.562 ng/mL was selected as the AMH cut-off value, the sensitivitywas 96% and specificity was 86%. the positive predictive value was92.3% and negative predictive value 97%. 3.serum AMH levels decreasewith age. |
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