Results Comparison Of Radiofrequency Ablation And Surgical Resection For Small Primary Liver Carcinoma.

Objective To compare the clinical results of surgical resection(SR) and radiofrequency ablation(RFA) for small primary liver carcinoma (≤5cm). Methods 88 patients in QingDao municipal hospital from Mar. 2000 to Nov. 2006 received surgical resection (n=42) and radiofrequency ablation(n=46), and the long-time results were anallized. Results with mean follow-up time 34.36 (6-72) months, The complete tumor elimination rates after first-time treatment in SR and RFA groups were 100%vs86.96%(P=0.03) and the rates of complication were 23.81% (10/42) vs 17.39%(8/46) (P=0.46), the recurrence rates were 52.38% (22/42) vs 69.56% (32/46) (P=0.10).The 1, 3, 5-year disease free survival rates in SR and RFA group were 85.4%, 40.9%, 29.2% vs 82.6%, 27.7%, 16.4%, the mean disease free survival time were 32.78mon. vs 29.39mon. (X~2=0.44, P=0.51)。when the tumor diameter =3cm, The 1, 3, 5-year disease free survival rates in SR and RFAgroup were 85.7%, 62.5%, 37.5% vs 85.0%, 37.4%, 29.9% (X~2=0.45, P=0.50). when the tumor diameter in 3～5cm, The 1, 3, 5-year disease free survival rates in SR and RFA group were 85.7%, 30.6%, 30.0% vs 80.8%, 21.8%, 10.9% (X~2=0.31, P=0.58). After balance the multiple factors' effect, Cox result shows the difference between SR and RFA was statistically not significant.The 1, 3, 5-year cumulative survival rates in SR and RFA group were 100%, 63.7%, 50.4% vs 100%, 66.3%, 37.4%, the mean cumulative survival time were 50.78 mon. vs 47.62 mon. (X~2=0.19, P=0.67)。when the tumor diameter≤3cm, The 1, 3, 5-year disease free survival rates in SR and RFA group werel00%, 78.8%, 59.1% vsl00%, 78.8%, 51.7%(X~2=0.03, P=0.87). when the tumor diameter in 3～5cm, The 1, 3, 5-year disease free survival rates in SR and RFA group were 100%, 56.8%, 45.4% vs 100%, 56.9%, 29.1% (X~2=0.68, P=0.41) .After balance the multiple factors' effect, Cox result shows the difference between SR and RFA was statistically not significant (P=0.85), but the tumor number was significately effect the survival time. Conclusion Radiofreqency ablation is a safe and satisfactory treatment for small liver carcinoma(≤5cm) with short and long-time results that similar to surgical resection, which could be selected to small liver carcinoma as one of the first-line treatments.