The Study On The Associativity Between The NT-proBNP And Congestive Heart Failure

Background Heart failure is not only a main diseases to threaten the human life, but also an end-life display in many cardiovascular diseases. Following the intervention of the advanced intervene, operation and the medication, many patients can survive who caught the cardiac arrhythmia and the acute myocardial infarction in the acute stage, but the incidence of the heart failure is becoming higher and higher, so it forces us to think highly of the early and (?)xcact diagnosis and treatment of the heart failure, thus we can lengthen the life and improve the life quality of the patients. The recent study has shown that it is not enough to diagnose the heart failure only by the clinical methods, thus searching for amore sensitive and specific biochemical indicator is becoming an urgent priority. The changing of concentration of the BNP can predict the prognosis of the congestive heart failure. Many studies have proved the close associativity between the plasma BNP concentration and the occurrence and degree of left ventricular reconstitution after congestive heart failure (CHF). It is an important clinical index to predict the prognosis of the patients who get the CHF using the BNP and left ventricular ejection fraction (LVEF). As a cardiac circulatory hormone, the main source of the BNP in the peripheral blood is the BNP precursor secreted by heart. Both BNP and NT-proBNP can not only facilitate the excretion of sodium and urine, but also relax the blood vessel comparatively stronger. They are the natural antagon of the RASS, and play an important role in maintaining the stabilization of the blood volume. Nevertheless, they have, close associativity with the severity and prognosis of the CHF. But we are short of these studies in this aspect in our country, so we can not provide the proof by ourselves, and all of us reported the results in according to the foreign reference. So we carry out this study.Object To observe the associativity between the plasma NT-proBNP concentration and the severity of CHF, and to determine the normal value of BNP and the influence by the age and sex and so on. We also determine the levels of NT-BNP in the different NYHA grade of the patients who catch the CHF, so we can definite the threshold to diagnose the CHF in our country, and improve the clinical diagnosis of CHF by our doctor, and direct the treatment.Methods To select 122 inpatients who caught CHF and were treated in the Qingdao Medical College affiliated cardiovascular hospital during 2005 and 2006, 20 patients in the control group had normal cardiac function. We determine the contents of serum NT-proBNP by electrochemiluminescence, and the LVEF and left ventriclelat end diastolic dimension (LVEDD) using cardiac ultrasound. We analyze the relationship between the NT-proBNP and LVEF with cardiac function, and carry out the statistical analysis.Result The level of NT proBNP in the heart failure group is obviously higher than the control group. And the differences of the levels of NT-proBNP between the different grades of the patients who caught the heart failure have statistical significance. Nevertheless, the differences of the levels of NT-proBNP between the subsets in the groups who caught different LVEF also have statistical significance, and they have negative correlation with, the LVEF. The changes of the concentration of NT-proBNP and LVEDD before and after the treatment in the cardiac failure group have statistical difference, and they have positive correlation with LVEDD.Conclusion The relationship between the concentration of NT-proBNP in the peripheral blood of the patients who catch CHF and the LVEF is obvious negative correlation.