Investigation Of The Relationship Between Ambulatory Blood Pressure Combining Carotid Artery Ultrasonography And Essential Hypertensive Disease Complicating Coronary Heart Disease

Objective: To investigate the relationship between the parameters of ambulatory blood pressure,the intimal-medial thickness (IMT) and plaques of carotid artery and essential hypertensive disease complicating coronary heart disease. To investigate clinical value of complicating coronary heart disease and extent of vascular lesion of essential hypertensive patients who underwent exami-nations of 24h ambulatory blood pressure monitoring and carotid artery ult-rasongraphy.Methods: We evaluated essential hypertensive patients who were suspected coronary heart disease and undergone examinations of coronary angiography in our department from 2005, 3 to 2007, 3．According to the outcome of coronary angiography we classified them into two groups: hypertensive disease co-mplicating coronary heart disease group (n=100 observe group ) ;hypertens-ive disease without complicating coronary heart disease group (n=100 con-trol group).All patients underwent examinations of 24h ambulatory blood pressure monitoring and carotid artery ultrasongraphy within one week be-fore or after coronary angiograph.Results: There was no difference between two groups of 24h DBPmax, 24h DBPm-in, mDBP, dayDBPmean, nightDBPmean, 24hMAP. (P > 0．05) 24h SBP max,24 hSBPmin,mSBP,daySBPmean,nightSBPmean of hypertensive dis-ease complicat-ing coronary heart disease group were higher than those of hypertensive without complicating coronary heart disease group. (P < 0．05 ) .Stepwise multinominal ordinal logistic regression showed that levels of pluse pressure can indicate severity of coronary lesions in patients with hy-pertensive disease complicating coronary heart disease. there was signific-ant difference among the patients with different severity of coronary artery lesion. PP of patients with 2 or 3 vessels lesion were higher than that of pa-tients with 1 vessel lesion.The rate of the intimal-medial thickness (IMT) of carotid artery and plaques in non-dipper was higher than that in dipper group . The intimal-medial thickness (IMT) of carotid artery and plaques are closely related with severity of coronary heart disease.Conclusion: 24h ambulatory blood pressure monitoring and carotid artery ultrasonog-raphy provide precise objective approach for comprehending the state of a-therosclerosis early,guiding rational depressurization treatment,interve-ting target-organ damage early in hypertensive patients. To learn them dee-ply can help reverse sub-clinical vascular lesion,which can lower cardiova-scular event to happen.