Study Of Relative Immunology Of Thyroid Arterial Embolization To Treat Hyperthyroidism Caused By Graves Disease

Objective To investigate the abnormity of immune function of Graves disease and the effect of thyroid arterial embolization to organism immune function by observing the change of relative immunology indexes before and after thyroid arterial embolization to treat hyperthyroidism caused by Graves disease. Meterials and Methods 1．Forty-one patients of hyperthyroidism caused by Graves disease by clinical definite had been treated through transcatheter arterial embolization, and curative effects were ascertained according to symptoms, signs and thyroid function during the postoperative follow-up of 3～54 months. 2．Autoimmune state of Graves disease before operation and dynamic changes of immune function after treatment were analyzed by regularly detecting the titre/activity and positive rate of serum thyroid auto-antibodies including thyrotropin receptor antibody (TRAb), thyroidal globulin antibody (TGAb) and thyroidal microsomal antibody (TMAb), and the proportion of lymphocyte subsets in peripheral blood including CD16⁺CD56⁺, CD19⁺, CD3⁺, CD3⁺CD4⁺ and CD3⁺CD8⁺ respectively at different period ( before thyroid arterial embolization and at 1^st month, 3^rd month, 6^th month, 1^st year and 3^rd year after operation).Results 1．The titre/activity and positive rate of TRAb, TGAb and TMAb, especially the ones of TRAb were higher than normal level, and the proportion of CD3⁺CD8⁺ in peripheral blood decreased and the ratio of CD4⁺/CD8⁺ increased in the patients with Graves disease. 2．In the utility group the activity and positive rate of TRAb and the ratio of CD4⁺/CD8⁺ decreased to normal level at 6^th month after interventional therapy, and the proportion of CD3⁺CD8⁺ gradually increased and got to normal level after 1^st year. The activity and positive rate of TRAb remained higher level than normal in the recurrence group. There were no remarkable differences both the proportion of CD3⁺CD8⁺ and the ratio of CD4⁺/CD8⁺ between before and after operation. Conclusion There is disorder of immune function in the patients with Graves disease, and we can detect the abnormity of serum thyroid auto-antibodies and lymphocyte subsets in peripheral blood. On the whole, the disorder of immune function can rectify among the responders performed interventional therapy, but scarcely among the recidivists. It demonstrates that thyroid arterial embolization to treat hyperthyroidism caused by Graves disease achieves significant curative effect by adjusting immune function disorders, and there is considerable significance to detect some immune indexes.