Relationship Between G894T Polymorphism Of Endothelial Nitric Oxide Synthase Gene And Acute Coronary Syndrome

Background Acute coronary syndrome(ACS) is composed of unstableangina pectoris(UAP) and acute myocardial infarction (AMI). Rupture ofatherosclerotic plaques superimposed with platelet aggregation and thrombusformation is believed to be responsible for most of the development of ACS.Recently, studies have shown that G894T polymorphism in exon 7 of theendothelial nitric oxide synthase gene(eNOS) is related to the development ofcoronary heart disease(CHD) and its risk factors, But Few studies have beenreported the association of G894T polymorphism with ACS.Objective To assess the effect of G894T polymorphism in exon 7 of theendothelial nitric oxide synthase gene(eNOS) on the development of acutecoronary syndromes (ACS) in Chinese Han nationality.Methods By means of Polymerase Chain Reaction-Restriction FragmentLength Polymorphism (PCR-RFLP) analysis, G894T polymorphism ofeNOS was detected in 260 patients with ACS (120 with AMI and 140 withUAP) and 248 subjects excluded CHD by coronary angiography.Results Genotypes GT+TT and T allele frequency in ACS group weresignificant higher than those in control group (23.46% vs 9.27%, 14.42% vs5.24 % respectively) (P＜0.01). There was no significant difference ingenotypes GT+TT between AMI subgroup and UAP subgroup(20.83 % vs 25.71%)(p＞0.05). That was not related to the number of coronary vesselsdiseased in patients with ACS either.ConclusionsG894T polymorphism of endothelial nitric oxide synthase gene might beassociated with ACS, and the T allele of eNOS gene might be a risk geneticmarker of CHD evolution into ACS. But that is not related to the severity ofcoronary vessels diseased.