The Relationship Between Magnesium Concentration In Serum And Cellular Immune Function In Patients With Head Injuries

Objective:To investigate the relationship between the inhibition of cellular immune function and the decrease of magnesium concentration in serum following head injuries, observe the change of cellular immune function following intravenous dripping of magnesium sulfate (MgSO₄), and discuss the mechanisms. Find a new way to reduce the incidence rate of complication of infection following head Injuries, prevent the appearance of drug fast bacterium because of the abuse of antibiotic, and improve the outcome of the patients with head injuries.Methods:In this prospective study, 45 patients with head injuries were divided randomly into two groups based on the Glasgow coma scale(GCS), sex and the order of being hospitalized: MgSO₄ group(22 cases) and control group(23cases). Measure the Mg²⁺ concentration in serum and T cell subset (CD3⁺,CD4⁺,CD8⁺)of all the cases in the 1^st, 4^th, 7^th, 14^th day after injury. Analyze the difference of the two groups and the correlations between the Mg²⁺ concentration in serum and T cell subset.Result:(1). The difference of the T cell subset between the two groups is significant in the 1^st, 4^th and7^th day (P<0.05). They are higher in MgSO₄ group than in control group.(2). In the 14^th day, only the difference of the CD4⁺ T cell between the two groups is significant. It is also higher in MgSO₄ group than in control group.(3). The rates of CD3⁺ T cell and CD4⁺ T cell have positive correlations with the Glasgow coma scale(GCS) of the patients in control group (P<0.05), the coefficients are 0.421 and 0.367.(4). The rates of CD3⁺ T cell, CD4⁺ T cell and CD8⁺ T cell have positive correlations with the Mg²⁺ concentration in serum (P＜0.05), the coefficients are 0.685,...