Simulation In Vitro On Inhibition Of Calcium Oxalate Calculus In Presence Of Inorganic Medicament

The growth of calcium oxalate (CaOxa) was investigated using Scanning Electron Microscope (SEM), X-ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FT-IR) in different simulation systems. We investigated the inhibition of the inorganic inhibitors medicament in the gel systems and in the aqueous solution systems, the inhibit mechanism was also discussed. These inorganic inhibitors medicament include magnesium tartrate, H₂EDTA and its Na⁺,K⁺, Mg²⁺ salts, H₃cit and its Na⁺, K⁺,(NH₄)⁺ salts ,sodium phosphate, sodium pyrophosphate, sodium triphosphate and sodium hexametaphosphate.Firstly, Mgtart can induce the growth of COD and COT. The ability of Mgtart to induce COT increased as increasing their concentration, but COD have no significant change, and the angles of COM crystals become more round. In the presence of MgCl₂, single crystal was increased, and the crystal became thin, it indicated that MgCl₂ could inhibit the aggregation of COM crystals.Secondly, H2EDTA and its Na⁺,K⁺,Mg²⁺ salts could inhibit the growth and aggregation of COM, and decrease the size of COM, decrease the specific surface area. Them all can induce the formation of COD, this ability increased with the increase of their concentrations. The relative ability follows the order: MgEDTA > K₂EDTA > Na₂EDTA> H₂EDTA.Thirdly, in the presence of citric acid and citrate, size of COM was decreased, and the aggregation were decreased, the edges was more round and the COD were existed. The result indicated that citric acid and citrate could inhibit the growth and aggregation of COM, all can induce the formation of COD, the relative ability follows the order: (NH₄)₃cit > K₃cit>>H₃cit > Na₃cit.Fourthly, the effect of various kinds of phosphates on the growth of COM crystals and the ability to induce COD decreased in the order: Na₅P₃O₁₀ > Na₄P₂O₇>> Na₃PO₄ > (NaPO₃)₆. This ability increased with the increase of their concentrations. It demonstrated the capacity of phosphates to induce COD and decrease the growth of COM was in favor of the prevention and cure of urinary stones.